CRCINA, Inserm, CNRS, Université de Nantes, 44000 Nantes, France.
Integrated Center for Oncology, ICO, 44800 St. Herblain, France.
Int J Mol Sci. 2021 Jun 17;22(12):6514. doi: 10.3390/ijms22126514.
Glioblastoma, a subset of aggressive brain tumors, deploy several means to increase blood vessel supply dedicated to the tumor mass. This includes typical program borrowed from embryonic development, such as vasculogenesis and sprouting angiogenesis, as well as unconventional processes, including co-option, vascular mimicry, and transdifferentiation, in which tumor cells are pro-actively engaged. However, these neo-generated vascular networks are morphologically and functionally abnormal, suggesting that the vascularization processes are rather inefficient in the tumor ecosystem. In this review, we reiterate the specificities of each neovascularization modality in glioblastoma, and, how they can be hampered mechanistically in the perspective of anti-cancer therapies.
胶质母细胞瘤是一种侵袭性脑肿瘤，会采用多种手段增加专门供应肿瘤的血管供应。这包括从胚胎发育中借鉴的典型程序，如血管生成和发芽血管生成，以及非传统过程，包括血管募集、血管模拟和转分化，其中肿瘤细胞积极参与。然而，这些新生成的血管网络在形态和功能上是异常的，这表明在肿瘤生态系统中血管生成过程效率低下。在这篇综述中，我们重申了胶质母细胞瘤中每种新血管生成方式的特异性，以及从抗癌治疗的角度来看，它们在机制上是如何受到阻碍的。
