关于再生医学在肌腱愈合中的应用的已知数据。

Lakhani Amit, Sharma Ena, Kapila Amit, Khatri Kavin

Dr Br Ambedkar State Institute of Medical Sciences, Mohali Punjab, India.

Maharishi Markandeshwar College of Dental Sciences and Hospital Mullana, Ambala, Haryana, India.

Bioinformation. 2021 Apr 30;17(4):514-527. doi: 10.6026/97320630017514. eCollection 2021.

Tendons and ligaments are important structures in the musculoskeletal system. Ligaments connect various bones and provide stability in complex movements of joints in the knee. Tendon is made of dense connective tissue and transmits the force of contraction from muscle to bone. They are injured due to direct trauma in sports or roadside accidents. Tendon healing after repair is often poor due to the formation of fibro vascular scar tissues with low mechanical property. Regenerative techniques such as PRP (platelet-rich plasma), stem cells, scaffolds, gene therapy, cell sheets, and scaffolds help augment repair and regenerate tissue in this context. Therefore, it is of interest to document known data (repair process, tissue regeneration, mechanical strength, and clinical outcome) on applied regenerative medicine in tendon healing.

肌腱和韧带是肌肉骨骼系统中的重要结构。韧带连接各种骨骼，并在膝关节复杂运动中提供稳定性。肌腱由致密结缔组织构成，将肌肉收缩力传递至骨骼。它们会因运动中的直接创伤或路边事故而受损。修复后的肌腱愈合通常较差，因为会形成机械性能较低的纤维血管瘢痕组织。在这种情况下，诸如富血小板血浆（PRP）、干细胞、支架、基因治疗、细胞片和支架等再生技术有助于增强修复并使组织再生。因此，记录应用再生医学在肌腱愈合方面的已知数据（修复过程、组织再生、机械强度和临床结果）很有意义。