Pieper R, Forsell P, Kager L
Acta Chir Scand Suppl. 1986;530:51-7.
This is a clinical study of 193 adult cases of perforating appendicitis during a nine-year period of treatment. There were 77 females (39.9%) and 116 males (60.1%) with ages of 15 years and above. Throughout the study period, the yearly perforation frequency ranged from 10.0 to 23.1% (mean 16.7%) of all cases with proven appendicitis. Perforation was equally common in both sexes, females: 15.5%, males: 17.6% of the appendicitis cases. In elderly patients (greater than or equal to 60 years of age) perforation was much more common; 37 out of 77 cases with proven appendicitis (48.1%). Compared to different ages (patients under and above 60 years of age), clinical and laboratory findings were found equal. Duration of symptoms showed no differences for younger and elderly patients. Preoperative delay in the hospital of at least 6 hours occurred in 39.9% of all patients, and was found equally common in patients younger than 60 years (39.1%) and in those from 60 years and older (43.2%). There were no fatalities in the study group. Postoperative septical complications predominated over non-septical (32.6 versus 9.3%), and were equally common in both sexes and in patients of different ages. The frequency of occurrence of septical complications was not significantly influenced by the duration of symptoms or by the duration of operation, furthermore, septical complications were equally frequent throughout the study period, although the use of antibiotics changed towards drugs more potent to cover anaerobic bacteria (28.1% infections for the period 1972-1976 versus 29.8% for the period 1977-1981).(ABSTRACT TRUNCATED AT 250 WORDS)
这是一项针对193例成人穿孔性阑尾炎患者在九年治疗期间的临床研究。其中女性77例(39.9%),男性116例(60.1%),年龄均在15岁及以上。在整个研究期间,每年穿孔性阑尾炎的发生率占所有确诊阑尾炎病例的10.0%至23.1%(平均16.7%)。穿孔在男女中发生率相当,女性穿孔性阑尾炎占阑尾炎病例的15.5%,男性占17.6%。在老年患者(年龄大于或等于60岁)中穿孔更为常见;77例确诊阑尾炎病例中有37例(48.1%)。与不同年龄组(60岁以下和60岁及以上患者)相比,临床和实验室检查结果相当。年轻和老年患者症状持续时间无差异。所有患者中39.9%术前在医院延误至少6小时,在60岁以下患者(39.1%)和60岁及以上患者(43.2%)中发生率相当。研究组无死亡病例。术后感染性并发症多于非感染性并发症(32.6%对9.3%),在男女及不同年龄患者中发生率相当。感染性并发症的发生频率不受症状持续时间或手术时间的显著影响,此外,在整个研究期间感染性并发症发生率相当,尽管抗生素的使用已转向更有效的覆盖厌氧菌的药物(1972 - 1976年期间感染率为28.1%,1977 - 1981年期间为29.8%)。(摘要截选至250字)