Macfarlane S D, Tauro G P
Am J Hematol. 1986 Aug;22(4):341-6. doi: 10.1002/ajh.2830220402.
Bone marrow necrosis has been regarded as an indicator of very poor prognosis in malignant disease. The cause and incidence are unknown, and reports of treatment response are few. We describe four children with marrow necrosis at presentation with acute lymphocytic leukemia (ALL), all of whom entered remission with standard treatment showing complete marrow healing. The bleak outlook for patients with marrow necrosis based on early experience in adults with disseminated malignancy does not appear to apply to children with ALL. The incidence of marrow necrosis at diagnosis of childhood ALL is 1%.
骨髓坏死一直被视为恶性疾病预后极差的一个指标。其病因和发病率尚不清楚，关于治疗反应的报道也很少。我们描述了4例在初诊急性淋巴细胞白血病（ALL）时伴有骨髓坏死的儿童，所有患儿经标准治疗后均进入缓解期，骨髓完全愈合。基于成人播散性恶性肿瘤早期经验得出的骨髓坏死患者预后不佳的观点，似乎并不适用于患有ALL的儿童。儿童ALL诊断时骨髓坏死的发生率为1%。
