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强调 CD8 T 细胞在丝虫感染中的相关性。

Highlighting the Relevance of CD8 T Cells in Filarial Infections.

机构信息

Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.

Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.

出版信息

Front Immunol. 2021 Sep 16;12:714052. doi: 10.3389/fimmu.2021.714052. eCollection 2021.

DOI:10.3389/fimmu.2021.714052
PMID:34603287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8481813/
Abstract

The T cell immune responses in filarial infections are primarily mediated by CD4 T cells and type 2-associated cytokines. Emerging evidence indicates that CD8 T cell responses are important for anti-filarial immunity, however, could be suppressed in co-infections. This review summarizes what we know so far about the activities of CD8 T cell responses in filarial infections, co-infections, and the associations with the development of filarial pathologies.

摘要

丝虫感染中的 T 细胞免疫反应主要由 CD4 T 细胞和 2 型相关细胞因子介导。新出现的证据表明，CD8 T 细胞反应对于抗丝虫免疫很重要，但在合并感染中可能受到抑制。本文综述了我们目前对丝虫感染、合并感染中 CD8 T 细胞反应的活性及其与丝虫病病理发展之间的关联的了解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40a/8481813/1cb41e87d354/fimmu-12-714052-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40a/8481813/fdfbeb9e14df/fimmu-12-714052-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40a/8481813/4f56ae1d7eab/fimmu-12-714052-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40a/8481813/1cb41e87d354/fimmu-12-714052-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40a/8481813/fdfbeb9e14df/fimmu-12-714052-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40a/8481813/4f56ae1d7eab/fimmu-12-714052-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40a/8481813/1cb41e87d354/fimmu-12-714052-g003.jpg

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filaria activates human dendritic cells and polarizes T helper 1 and regulatory T cells via toll-like receptor 4.丝虫通过 Toll 样受体 4 激活人树突状细胞，并使其向 T 辅助 1 细胞和调节性 T 细胞极化。
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