Li Xinke, Yu Da, Wang Yushuang, Yuan Huimin, Ning Xixi, Rui Binqi, Lei Zengjie, Yuan Jieli, Yan Jingyu, Li Ming
Dalian Medical University, Dalian, Liaoning 116044, China.
Department of Obstetrics, Dalian Women and Children's Medical Group, Dalian, China.
Can J Infect Dis Med Microbiol. 2021 Sep 22;2021:3044534. doi: 10.1155/2021/3044534. eCollection 2021.
Gestational diabetes mellitus (GDM) is defined as "diagnosed as impaired glucose tolerance for the first time during pregnancy," which can lead to adverse pregnancy outcomes and produces divergent effects on mothers and newborns. In recent years, with the continuous expansion of obese people, GDM shows an upward trend. The abundant and diverse members of the human gut microbiota exert critical roles in the maintenance of human health. Studies have shown that GDM may be associated with disordered gut microbiota in both mothers and newborns. Taking into account the potential effects on maternal and consequently neonatal health, in this review, we analyzed the available data and discussed the current knowledge about the potential relationship between GDM and intestinal dysbiosis in mothers and newborns. In addition, we also discussed the influencing factors derived from GDM mothers on the gut microbiome of their newborns, including the vertical transmission of microbiota from mothers, the alteration of milk components of GDM mothers, and using of probiotics. Hoping that new insights into the role of the gut microbiota in GDM could lead to the development of integrated strategies to prevent and treat these metabolic disorders.
妊娠期糖尿病（GDM）被定义为“在孕期首次被诊断为糖耐量受损”，它可导致不良妊娠结局，并对母亲和新生儿产生不同影响。近年来，随着肥胖人群的不断扩大，GDM呈上升趋势。人类肠道微生物群丰富多样的成员在维持人类健康方面发挥着关键作用。研究表明，GDM可能与母亲和新生儿的肠道微生物群紊乱有关。考虑到对母亲及随后新生儿健康的潜在影响，在本综述中，我们分析了现有数据，并讨论了关于GDM与母亲和新生儿肠道生态失调之间潜在关系的当前知识。此外，我们还讨论了GDM母亲对其新生儿肠道微生物组的影响因素，包括微生物群从母亲的垂直传播、GDM母亲乳汁成分的改变以及益生菌的使用。希望对肠道微生物群在GDM中作用的新见解能够促成预防和治疗这些代谢紊乱的综合策略的发展。
