Zheng Wei, Xu Qian, Huang Wenyu, Yan Qi, Chen Yating, Zhang Li, Tian Zhihong, Liu Ting, Yuan Xianxian, Liu Cheng, Luo Jinying, Guo Cuimei, Song Wei, Zhang Lirui, Liang Xin, Qin Huanlong, Li Guanghui
Division of Endocrinology and Metabolism, Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Realbio Genomics Institute, Shanghai, China.
mSystems. 2020 Mar 24;5(2):e00109-20. doi: 10.1128/mSystems.00109-20.
Women with gestational diabetes mellitus (GDM) have different gut microbiota in late pregnancy compared to women without GDM. It remains unclear whether alterations of gut microbiota can be identified prior to the diagnosis of GDM. This study characterized dynamic changes of gut microbiota from the first trimester (T1) to the second trimester (T2) and evaluated their relationship with later development of GDM. Compared with the control group ( = 103), the GDM group ( = 31) exhibited distinct dynamics of gut microbiota, evidenced by taxonomic, functional, and structural shifts from T1 to T2. Linear discriminant analysis (LDA) revealed that there were 10 taxa in T1 and 7 in T2 that differed in relative abundance between the GDM and control groups, including a consistent decrease in the levels of and in the GDM group. While the normoglycemic women exhibited substantial variations of gut microbiota from T1 to T2, their GDM-developing counterparts exhibited clearly reduced inter-time point shifts, as corroborated by the results of Wilcoxon signed-rank test and balance tree analysis. Moreover, cooccurrence network analysis revealed that the interbacterial interactions in the GDM group were minimal compared with those in the control group. In conclusion, lower numbers of dynamic changes in gut microbiota in the first half of pregnancy are associated with the development of GDM. GDM is one of the most common metabolic disorders during pregnancy and is associated with adverse short-term and long-term maternal and fetal outcomes. The aim of this study was to examine the connection between dynamic variations in gut microbiota and development of GDM. Whereas shifts in gut microbiota composition and function have been previously reported to be associated with GDM, very little is known regarding the early microbial changes that occur before the diagnosis of GDM. This study demonstrated that the dynamics in gut microbiota during the first half of pregnancy differed significantly between GDM and normoglycemic women. Our findings suggested that gut microbiota may potentially serve as an early biomarker for GDM.
与未患妊娠期糖尿病（GDM）的女性相比，患有GDM的女性在妊娠晚期肠道微生物群不同。目前尚不清楚在GDM诊断之前是否能够识别肠道微生物群的改变。本研究对从孕早期（T1）到孕中期（T2）肠道微生物群的动态变化进行了特征分析，并评估了它们与GDM后期发展的关系。与对照组（n = 103）相比，GDM组（n = 31）表现出明显不同的肠道微生物群动态变化，从T1到T2的分类、功能和结构变化证明了这一点。线性判别分析（LDA）显示，T1时有10个分类群，T2时有7个分类群在GDM组和对照组之间的相对丰度存在差异，包括GDM组中[具体分类群1]和[具体分类群2]水平持续下降。虽然血糖正常的女性从T1到T2肠道微生物群有很大变化，但发展为GDM的女性肠道微生物群在不同时间点的变化明显减少，威尔科克森符号秩检验和平衡树分析结果证实了这一点。此外，共现网络分析显示，与对照组相比，GDM组中细菌间的相互作用最小。总之，妊娠前半期肠道微生物群动态变化数量较少与GDM的发生有关。GDM是孕期最常见的代谢紊乱之一，与母婴不良的短期和长期结局相关。本研究的目的是研究肠道微生物群的动态变化与GDM发生之间的联系。虽然先前已报道肠道微生物群组成和功能的变化与GDM有关，但对于GDM诊断之前发生的早期微生物变化知之甚少。本研究表明，GDM女性和血糖正常女性在妊娠前半期肠道微生物群的动态变化存在显著差异。我们的研究结果表明，肠道微生物群可能潜在地作为GDM的早期生物标志物。
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