加纳HIV阳性人群中黄曲霉毒素B1白蛋白加合物水平与结核感染之间的关联
Association Between Aflatoxin B1 Albumin Adduct Levels and Tuberculosis Infection Among HIV+ Ghanaians.
作者信息
Keenan John, Jolly Pauline, Preko Peter, Baidoo Joseph, Wang Jia-Sheng, Phillips Timothy D, Williams Jonathan H, McGwin Gerald
机构信息
University of Alabama at Birmingham, Birmingham, Alabama, School of Public Health.
St. Markus Hospital, Kumasi, Ghana.
出版信息
Arch Clin Microbiol. 2011;2(3).
BACKGROUND
Aflatoxin exposure has been shown to cause cell-mediated immune suppression and enhance HIV viral replication. Such immune suppression from aflatoxin can impair resistance to both infectious diseases and chronic infections.
METHODS
Hazard ratios (HRs) with 95% confidence intervals (CI) and a test for trend for opportunistic infections OI) among 141 HIV positive Ghanaians based on quartiles of aflatoxin B1 albumin adduct levels (AF-ALB) were calculated.
FINDINGS
HRs were significantly higher for developing symptomatic TB (HR 3.30, 95% CI 1.34-8.11) for those in the highest AF-ALB quartile compared to the lowest. Significantly higher HRs were not observed for other infections investigated.
CONCLUSIONS
Those with the highest levels AF-ALB from dietary intake have an increased hazard of symptomatic TB but not malaria, HBV, or pneumonia.
背景
黄曲霉毒素暴露已被证明会导致细胞介导的免疫抑制并增强HIV病毒复制。黄曲霉毒素引起的这种免疫抑制会削弱对传染病和慢性感染的抵抗力。
方法
根据黄曲霉毒素B1白蛋白加合物水平（AF-ALB）的四分位数，计算了141名HIV阳性加纳人的风险比（HRs）及95%置信区间（CI），并对机会性感染（OI）进行了趋势检验。
结果
与最低AF-ALB四分位数组相比，最高AF-ALB四分位数组发生有症状结核病的HRs显著更高（HR 3.30，95% CI 1.34 - 8.11）。对于所调查的其他感染，未观察到显著更高的HRs。
结论
饮食摄入中AF-ALB水平最高的人群发生有症状结核病的风险增加，但疟疾、乙肝或肺炎的风险未增加。
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