……中Y RNA的年龄依赖性上调
Age-dependent upregulation of Y RNAs in .
作者信息
Park Sangsoon, Sohn Jooyeon, Kwon Sujeong, Kim Eun Ji E, Jung Yoonji, Park Hae-Eun H, Kim Sieun S, Lee Seung-Jae V
机构信息
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, South Korea.
出版信息
MicroPubl Biol. 2021 Sep 27;2021. doi: 10.17912/micropub.biology.000452. eCollection 2021.
Y RNA is a conserved small non-coding RNA whose functions in aging remain unknown. Here, we sought to determine the role of Y RNA homologs, CeY RNA (CeY) and stem-bulge RNAs (sbRNAs), in aging. We found that the levels of CeY and sbRNAs generally increased during aging. We showed that CeY was downregulated by oxidative and thermal stresses, whereas several sbRNAs were upregulated by oxidative stress. We did not observe lifespan phenotypes by mutations in CeY-coding . Future research under various genetic and environmental conditions is required to further evaluate the role of Y RNA in aging.
Y RNA是一种保守的小非编码RNA，其在衰老过程中的功能尚不清楚。在这里，我们试图确定Y RNA同源物CeY RNA（CeY）和茎环RNA（sbRNAs）在衰老中的作用。我们发现，CeY和sbRNAs的水平在衰老过程中普遍升高。我们表明，CeY在氧化应激和热应激下被下调，而几种sbRNAs在氧化应激下被上调。我们没有观察到CeY编码基因突变导致的寿命表型。需要在各种遗传和环境条件下进行进一步研究，以进一步评估Y RNA在衰老中的作用。
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