RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA; email:
Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06510, USA.
Annu Rev Microbiol. 2020 Sep 8;74:387-407. doi: 10.1146/annurev-micro-020620-062812. Epub 2020 Jul 13.
Ro60 ribonucleoproteins (RNPs), composed of the ring-shaped Ro 60-kDa (Ro60) protein and noncoding RNAs called Y RNAs, are present in all three domains of life. Ro60 was first described as an autoantigen in patients with rheumatic disease, and Ro60 orthologs have been identified in 3% to 5% of bacterial genomes, spanning the majority of phyla. Their functions have been characterized primarily in , the first sequenced bacterium with a recognizable ortholog. In , the Ro60 ortholog enhances the ability of 3'-to-5' exoribonucleases to degrade structured RNA during several forms of environmental stress. Y RNAs are regulators that inhibit or allow the interactions of Ro60 with other proteins and RNAs. Studies of Ro60 RNPs in other bacteria hint at additional functions, since the most conserved Y RNA contains a domain that is a close tRNA mimic and Ro60 RNPs are often encoded adjacent to components of RNA repair systems.
Ro60 核糖核蛋白（RNP）由环形的 Ro60kDa（Ro60）蛋白和称为 Y RNA 的非编码 RNA 组成，存在于所有三个生命领域。Ro60 最初被描述为风湿性疾病患者的自身抗原，并且在 3%到 5%的细菌基因组中鉴定出了 Ro60 同源物，涵盖了大多数门。它们的功能主要在 中进行了表征， 是第一个具有可识别同源物的测序细菌。在 中，Ro60 同源物增强了 3'-5'外切核糖核酸酶在几种形式的环境应激下降解结构 RNA 的能力。Y RNA 是调节因子，可抑制或允许 Ro60 与其他蛋白质和 RNA 相互作用。在其他细菌中对 Ro60 RNP 的研究暗示了其他功能，因为最保守的 Y RNA 包含一个与 tRNA 非常相似的结构域，并且 Ro60 RNP 通常编码在 RNA 修复系统组件的旁边。
