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弓形虫感染与 COVID-19 合并精神分裂症患者死亡率升高之间的联系。

The link between Toxoplasma gondii infections and higher mortality in COVID-19 patients having schizophrenia.

机构信息

, San Jose, CA, USA.

出版信息

Eur Arch Psychiatry Clin Neurosci. 2022 Feb;272(1):167-168. doi: 10.1007/s00406-021-01341-0. Epub 2021 Oct 4.

Abstract

A strong link between schizophrenia and a higher mortality rate from SARS-CoV-2 infections has been reported for schizophrenia patients, with a mortality odds ratio (OR) of 2.67 compared to normal patients, after adjustment of the OR for age, sex, race and extra risk factors. In addition, an extensive number of papers have reported a very strong link between schizophrenia and Toxoplasma gondii infections. A meta-analysis of 38 studies of links between schizophrenia and T. gondii antibody seroprevalence resulting from previous infections indicated that the likelihood of T. gondii infection in schizophrenia patients was 2.7 times higher than the general population. In other words, the meta-analysis indicated that schizophrenia patients had an odds ratio of 2.7 of T. gondii infection compared to the general population. This indicates that compared to the general population, schizophrenia patients have virtually the same odds ratio for having a T. gondii infection and for mortality from a COVID-19 infection. This suggests that T. gondii infections, directly or indirectly, have a relationship with higher mortality in COVID-19 patients having schizophrenia. This conclusion would also apply to the general population.

摘要

有研究报道,精神分裂症患者与 SARS-CoV-2 感染导致的死亡率升高之间存在很强的关联,校正年龄、性别、种族和其他危险因素后,精神分裂症患者的死亡率比值比(OR)为 2.67。此外,大量文献报道精神分裂症与弓形虫感染之间存在很强的关联。对 38 项关于精神分裂症与既往感染弓形虫抗体阳性率之间关系的研究进行荟萃分析表明,精神分裂症患者弓形虫感染的可能性比普通人群高 2.7 倍。换句话说,荟萃分析表明,与普通人群相比,精神分裂症患者感染弓形虫的几率是普通人群的 2.7 倍。这表明,与普通人群相比,精神分裂症患者感染弓形虫的几率和感染 COVID-19 后死亡的几率几乎相同。这表明,弓形虫感染与 COVID-19 患者精神分裂症死亡率升高直接或间接相关。这一结论也适用于普通人群。

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