Haghparast Zahra, Ghaffarifar Fatemeh, Sharifi Zohreh, Bahadory Saeed
Department of Parasitology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
Biological Products and Blood Safety Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Iran J Parasitol. 2025 Jan-Mar;20(1):140-147. doi: 10.18502/ijpa.v20i1.18114.
Theoretically, there is a possible association between emerging SARS-CoV-2 infection and parasites such as . We aimed to evaluate the seroepidemiology of in COVID-19 patients and the control group as well as its correlation with risk factors.
Totally, 450 sera samples were taken from COVID-19 positive patients and controls from the Tehran, Karaj, and Shiraz cities, Iran. Anti- IgG and IgM were evaluated using the ELISA technique. After two months, the participants were followed for recovery or non-recovery and even death. The association between seroprevalence and severity of viral infection as well as other risk factors was statistically estimated.
IgG prevalence in patients and healthy individuals was 59.11% and 61.77%, respectively; these values were estimated at 2.22% and 0% for IgM, respectively. There was no significant association between the prevalence of IgG with COVID-19 infection, while this association was statistically significant for IgM prevalence. The Karaj had the highest prevalence, and a significant association was observed between the seroprevalence and some variables.
Despite the non-significant association between the chronic phase of (sero) prevalence and COVID-19 symptomatic forms, the parasite prevalence was estimated remarkable and the viral infection and parasite-related acute phase antibodies relationship was estimated to be statistically significant. Due to immunosuppressive therapies for this viral inflammatory infection, it makes it more difficult to interpret the results, and because of the vulnerability of the immune system of these individuals, toxoplasmosis is likely to be hazardous in them; therefore, screening for this parasitic complication seems necessary.
从理论上讲，新出现的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染与诸如[寄生虫名称未给出]等寄生虫之间可能存在关联。我们旨在评估[寄生虫名称未给出]在新冠肺炎患者和对照组中的血清流行病学及其与危险因素的相关性。
总共从伊朗德黑兰、卡拉季和设拉子市的新冠肺炎阳性患者及对照组中采集了450份血清样本。使用酶联免疫吸附测定（ELISA）技术评估抗[寄生虫名称未给出]免疫球蛋白G（IgG）和免疫球蛋白M（IgM）。两个月后，对参与者进行随访，观察其康复或未康复甚至死亡情况。对血清阳性率与病毒感染严重程度以及其他危险因素之间的关联进行统计学评估。
患者和健康个体中IgG的阳性率分别为59.11%和61.77%；IgM的阳性率分别估计为2.22%和0%。IgG阳性率与新冠肺炎感染之间无显著关联，而IgM阳性率的这种关联具有统计学意义。卡拉季的阳性率最高，并且在血清阳性率与一些变量之间观察到显著关联。
尽管[寄生虫名称未给出]（血清）阳性率的慢性期与新冠肺炎症状形式之间无显著关联，但寄生虫阳性率估计较高，且病毒感染与寄生虫相关急性期抗体之间的关系估计具有统计学意义。由于针对这种病毒性炎症感染的免疫抑制疗法，使得结果更难解释，并且由于这些个体免疫系统的脆弱性，弓形虫病在他们身上可能具有危险性；因此，对这种寄生虫并发症进行筛查似乎很有必要。
