使用正电子发射断层扫描/磁共振成像技术评估睡眠时长与血管炎症的关系：来自动脉粥样硬化多民族研究的结果。

Sleep duration and vascular inflammation using hybrid positron emission tomography/magnetic resonance imaging: results from the Multi-Ethnic Study of Atherosclerosis.

机构信息

Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Brigham and Women's Hospital, Boston, Massachusetts.

出版信息

J Clin Sleep Med. 2021 Oct 1;17(10):2009-2018. doi: 10.5664/jcsm.9382. Epub 2021 May 10.

DOI:10.5664/jcsm.9382

PMID:34606438

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8494091/

Abstract

STUDY OBJECTIVES

Short sleep duration (SD) is associated with cardiovascular disease. We investigated the relationship between objective SD and subclinical atherosclerosis employing hybrid positron emission tomography/magnetic resonance imaging with F-FDG tracer in the MESA cohort.

METHODS

We utilized data from Multi-Ethnic Study of Atherosclerosis-SLEEP and Multi-Ethnic Study of Atherosclerosis-PET ancillary studies. SD and sleep fragmentation index (SFI) were assessed using 7-day actigraphy. The primary and secondary outcomes were carotid inflammation, defined using target-to-background ratios, and measures of carotid wall remodeling (carotid wall thickness), summarized by SD category. Multivariable linear regression was performed to assess the association between SD and SFI with the primary/secondary outcomes, adjusting for several covariates including apnea-hypopnea index, and cardiovascular disease risk.

RESULTS

Our analytical sample (n = 58) was 62% female (mean age 68 ± 8.4 years). Average SD was 5.1 ± 0.9 hours in the short SD group (≤ 6 h/night, 31%), and 7.1 ± 0.8 hours in the normal SD group (69%). Prevalence of pathologic vascular inflammation (maximal target-to-background ratio > 1.6) was higher in the short SD group (89% vs 53%, = .01). Those with short SD had a higher maximal target-to-background ratio (1.77 vs 1.71), although this was not statistically significant ( = .39). Carotid wall thickness was positively associated with SFI even after adjusting for covariates (Beta [standard error] = 0.073 ± [0.032], = .03).

CONCLUSIONS

Prevalence of pathologic vascular inflammation was higher among those who slept ≤ 6 hours, and vascular inflammation was higher among those with a SD of ≤ 6 hours. Interestingly, SFI was positively associated with carotid wall thickness even after adjustment for covariates. Our results are hypothesis generating but suggest that both habitual SD and SFI should be investigated in future studies as potential risk factors for subclinical atherosclerosis.

CITATION

Kundel V, Reid M, Fayad Z, et al. Sleep duration and vascular inflammation using hybrid positron emission tomography/magnetic resonance imaging: results from the Multi-Ethnic Study of Atherosclerosis. . 2021;17(10):2009-2018.

摘要

研究目的

睡眠持续时间（SD）较短与心血管疾病有关。我们使用 F-FDG 示踪剂的正电子发射断层扫描/磁共振成像混合方法，在 MESA 队列中研究了客观 SD 与亚临床动脉粥样硬化之间的关系。

方法

我们利用了多民族动脉粥样硬化研究-睡眠和多民族动脉粥样硬化研究-正电子发射断层扫描辅助研究的数据。SD 和睡眠碎片化指数（SFI）通过 7 天活动记录仪进行评估。主要和次要结果是使用目标与背景比定义的颈动脉炎症，以及通过 SD 类别总结的颈动脉壁重塑（颈动脉壁厚度）。多变量线性回归用于评估 SD 和 SFI 与主要/次要结果之间的关系，调整了包括呼吸暂停低通气指数和心血管疾病风险在内的几个协变量。

结果

我们的分析样本（n=58）中 62%为女性（平均年龄 68±8.4 岁）。短 SD 组（≤6 小时/夜，31%）的平均 SD 为 5.1±0.9 小时，正常 SD 组为 7.1±0.8 小时。短 SD 组病理性血管炎症（最大目标与背景比>1.6）的患病率更高（89% vs.53%，=0.01）。尽管差异无统计学意义（=0.39），但短 SD 组的最大目标与背景比更高（1.77 vs.1.71）。颈动脉壁厚度与 SFI 呈正相关，即使在调整协变量后也是如此（β[标准误差] = 0.073±[0.032]，=0.03）。