Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Medical Department, Yidu Cloud (Beijing) Technology Co., Ltd., Beijing 100191, China.
Ageing Res Rev. 2021 Dec;72:101481. doi: 10.1016/j.arr.2021.101481. Epub 2021 Oct 1.
Iron is an essential element for proper functioning of cells within mammalian organ systems; in particular, iron homeostasis is critical for joint health. Excess iron can induce oxidative stress damage, associated with the pathogenesis of iron-storage and ageing-related diseases. Therefore, iron levels in body tissues and cells must be tightly regulated. In the past decades, excess iron content within joints has been found in some patients with joint diseases including hemophilic arthropathy, hemochromatosis arthropathy, and osteoarthritis (OA). Currently, increased evidence has shown that iron accumulation is closely associated with multiple pathological changes of these arthropathies. This review summarizes system-level and intracellular regulation of iron homeostasis, and emphasizes the role of iron in synovial alterations, cartilage degeneration, and subchondral bone of several arthropathies. Of note, we discuss the potential link between iron homeostasis and OA pathogenesis. Finally, we discuss the therapeutic potential of maintaining iron homeostasis in these arthropathies.
铁是哺乳动物器官系统内细胞正常功能所必需的元素；特别是，铁稳态对于关节健康至关重要。过量的铁会引起氧化应激损伤，与铁储存和与年龄相关的疾病的发病机制有关。因此，体内组织和细胞中的铁含量必须严格控制。在过去的几十年中，在一些患有关节疾病的患者中发现关节内存在过量的铁，这些疾病包括血友病性关节炎、血色病性关节炎和骨关节炎（OA）。目前，越来越多的证据表明，铁积累与这些关节炎的多种病理变化密切相关。本综述总结了铁稳态的系统和细胞内调节，并强调了铁在滑膜改变、软骨退化和几种关节炎的软骨下骨中的作用。值得注意的是，我们讨论了铁稳态与 OA 发病机制之间的潜在联系。最后，我们讨论了在这些关节炎中维持铁稳态的治疗潜力。
