Méndez Raúl, González-Jiménez Paula, Latorre Ana, Piqueras Mónica, Bouzas Leyre, Yépez Katheryn, Ferrando Ana, Zaldívar-Olmeda Enrique, Moscardó Antonio, Alonso Ricardo, Reyes Soledad, Menéndez Rosario
Pneumology, La Fe University and Polytechnic Hospital, Valencia, Spain
Respiratory Infections, Health Research Institute La Fe, Valencia, Spain.
Thorax. 2022 Apr;77(4):400-403. doi: 10.1136/thoraxjnl-2020-216797. Epub 2021 Oct 4.
Endothelial injury is related to poor outcomes in respiratory infections yet little is known in relation to COVID-19. Performing a longitudinal analysis (on emergency department admission and post-hospitalisation follow-up), we evaluated endothelial damage via surrogate systemic endothelial biomarkers, that is, proadrenomedullin (proADM) and proendothelin, in patients with COVID-19. Higher proADM and/or proendothelin levels at baseline were associated with the most severe episodes and intensive care unit admission when compared with ward-admitted individuals and outpatients. Elevated levels of proADM or proendothelin at day 1 were associated with in-hospital mortality. High levels maintained after discharge were associated with reduced diffusing capacity.
内皮损伤与呼吸道感染的不良预后相关，但关于新型冠状病毒肺炎（COVID-19）的相关情况却知之甚少。我们通过对急诊科入院和出院后随访进行纵向分析，利用替代系统性内皮生物标志物，即前肾上腺髓质素（proADM）和前内皮素，评估了COVID-19患者的内皮损伤情况。与病房收治患者和门诊患者相比，基线时较高的proADM和/或前内皮素水平与最严重发作及入住重症监护病房相关。第1天时proADM或前内皮素水平升高与院内死亡相关。出院后维持的高水平与弥散能力降低相关。
