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解析儿童多系统炎症综合征（MIS-C）中静脉注射免疫球蛋白（IVIG）免疫疗法的作用机制。

Unraveling the mechanisms of IVIG immunotherapy in MIS-C.

机构信息

Division of Pediatric Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.

Division of Pediatric Cardiology, Children's Hospital of San Antonio/Baylor College of Medicine, San Antonio, TX 78207, USA.

出版信息

Cell Rep Med. 2021 Oct 19;2(10):100431. doi: 10.1016/j.xcrm.2021.100431. Epub 2021 Sep 30.

DOI:10.1016/j.xcrm.2021.100431
PMID:34608458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8481087/
Abstract

In , Zhu et al. report that intravenous immunoglobulin (IVIG) targets IL-1β neutrophils to exert anti-inflammatory effects in multisystem inflammatory syndrome in children (MIS-C), a post-infectious inflammatory condition associated with COVID-19.

摘要

在[文献]中，Zhu 等人报告称，静脉注射免疫球蛋白（IVIG）靶向白细胞介素-1β中性粒细胞，在与 COVID-19 相关的感染后炎症性疾病儿童多系统炎症综合征（MIS-C）中发挥抗炎作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dd1/8561310/96574ac5b800/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dd1/8561310/96574ac5b800/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8dd1/8561310/96574ac5b800/gr1.jpg

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iScience. 2021 Nov 19;24(11):103215. doi: 10.1016/j.isci.2021.103215. Epub 2021 Oct 2.
2
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J Clin Invest. 2021 Oct 15;131(20). doi: 10.1172/JCI147076.
3
Similarities and Differences Between COVID-19-Related Multisystem Inflammatory Syndrome in Children and Kawasaki Disease.
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Sci Rep. 2025 Feb 7;15(1):4669. doi: 10.1038/s41598-025-88976-4.
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Apoptosis. 2025 Apr;30(3-4):734-750. doi: 10.1007/s10495-024-02064-y. Epub 2024 Dec 25.
5
Multisystem Inflammatory Syndrome in Children: A Case Report.儿童多系统炎症综合征：一例报告
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6
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