人类大脑发育与疾病中的染色质动力学
Chromatin dynamics in human brain development and disease.
作者信息
Valencia Alfredo M, Pașca Sergiu P
机构信息
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA 94305, USA.
出版信息
Trends Cell Biol. 2022 Feb;32(2):98-101. doi: 10.1016/j.tcb.2021.09.001. Epub 2021 Oct 2.
Chromatin-related genes are frequently mutated in neurodevelopmental disorders; yet, the mechanisms by which these perturbations disrupt brain assembly and function are not understood. Here, we describe how recent advances in transcriptional and chromatin profiling in combination with cellular models are beginning to inform our understanding of neurodevelopment and chromatinopathies.
染色质相关基因在神经发育障碍中经常发生突变；然而，这些扰动破坏大脑组装和功能的机制尚不清楚。在这里，我们描述了转录和染色质分析的最新进展与细胞模型相结合是如何开始增进我们对神经发育和染色质病的理解的。
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