Faculty of Medicine, Department of Ophthalmology, University Hospital of Ioannina, Ioannina, Greece.
Faculty of Medicine, Department of Neurology, University Hospital of Ioannina, Ioannina, Greece.
Semin Ophthalmol. 2022 Apr 3;37(3):399-407. doi: 10.1080/08820538.2021.1987482. Epub 2021 Oct 6.
Given the fact that retina may provide a window into the central nervous system, there has been interest in identifying retinal biomarkers as predicting factors of pathological processes in neurodegenerative disorders. Emerging evidence has suggested that macular microcirculation changes in Parkinson disease (PD) may indicate the alterations of cerebral microvasculature. The use of Optical Coherence Tomography Angiography (OCT-A) has attracted significant attention in recent years as this technique offers a detailed analysis of the existence of changes at the macular capillary plexus.
A detailed review of the literature was performed in PubMed until June 2021. We identified all papers referring to the alterations of the macular capillary plexus in PD using OCT-A.
A comprehensive update indicates that microvasculature alterations of the macular capillary plexus utilizing OCT-A may comprise useful biomarkers regarding the cerebral vasculature in PD. Since the available evidence is limited, additional studies are warranted to establish the OCT-A parameters as predicting factors in clinical practice.
A review of the existing literature sheds light on the microvasculature changes of the macular capillary plexus as seen on OCT-A in PD patients. The current article discusses notable aspects of key publications on the topic, highlights the importance of the potential long-term effectiveness of OCT-A biomarkers in PD and proposes the need for further future research.
鉴于视网膜可能为中枢神经系统提供一个窗口，因此人们一直有兴趣寻找视网膜生物标志物作为神经退行性疾病中病理过程的预测因素。新出现的证据表明，帕金森病（PD）中的黄斑微循环变化可能表明脑微血管的改变。近年来，光学相干断层扫描血管造影（OCT-A）的应用引起了人们的极大关注，因为这项技术可以详细分析黄斑毛细血管丛存在的变化。
我们在 PubMed 上进行了详细的文献回顾，直到 2021 年 6 月。我们确定了所有使用 OCT-A 研究 PD 黄斑毛细血管丛改变的论文。
全面更新表明，利用 OCT-A 对黄斑毛细血管丛的微血管改变可能包含与 PD 中脑血管有关的有用生物标志物。由于现有证据有限，需要进一步的研究来确定 OCT-A 参数是否可以作为临床实践中的预测因素。
对现有文献的回顾阐明了 PD 患者 OCT-A 所见黄斑毛细血管丛的微血管变化。本文讨论了该主题的重要出版物的一些显著方面，强调了 OCT-A 生物标志物在 PD 中潜在长期有效性的重要性，并提出了进一步开展未来研究的必要性。
