Jiang Hong, Stremousov Kirill, Dai Yunhai, Levin Bonnie, Virgets Amanda, Hoover Andrew, Martinez Kylie J, Signorile Joseph, Wang Jianhua
Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL 33136, USA.
Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Clin Park Relat Disord. 2025 Apr 23;12:100329. doi: 10.1016/j.prdoa.2025.100329. eCollection 2025.
To determine the relationship of retinal microcirculatory responses to cognitive function following yoga training in patients with Parkinson's disease (PD).
Twenty patients with diagnosed PD were recruited, and retinal imaging was successful on 17 patients (age 71.8 ± 7.2 years old, nine females). Retinal capillary perfusion density (CPD) was imaged using optical coherence tomography angiography (OCTA), and retinal blood flow (RBF) was imaged using a retinal function imager (RFI). All patients participated in three 1-hour YogaCue or Hatha yoga classes per week for 24 consecutive weeks. Pearson correlation analyses determined the relationship between the changes in retinal microcirculatory responses and cognitive function.
Increased RBF was significantly related to the changes of CPD in all retinal slabs, including superficial and deeper vascular plexuses and retinal vascular network (6 mm scan, r ranged 0.58-0.83, P < 0.05). The increased RBF and CPD of superficial vascular plexus (6 mm scan) were related to the improvements (i.e., shorter time) in trail-making A performance (r = -0.66, P < 0.01 and r = -0.58, P < 0.05, respectively). In addition, the change of CPD in the retinal vascular network was related to improvement in Hopkins verbal delayed recall (r = 0.50, P < 0.05).
This is the first study exploring the relationship between retinal microcirculatory responses to yoga exercise and cognitive function in PD patients. The synergistic effect of CPD and RBF may be developed into ocular indicators for monitoring the effect of cognitive improvement from yoga exercise in patients with PD.
确定帕金森病（PD）患者在瑜伽训练后视网膜微循环反应与认知功能之间的关系。
招募20例确诊为PD的患者，17例患者（年龄71.8±7.2岁，9例女性）视网膜成像成功。使用光学相干断层扫描血管造影（OCTA）对视网膜毛细血管灌注密度（CPD）进行成像，使用视网膜功能成像仪（RFI）对视网膜血流（RBF）进行成像。所有患者连续24周每周参加3节1小时的YogaCue或哈他瑜伽课程。Pearson相关性分析确定视网膜微循环反应变化与认知功能之间的关系。
RBF增加与所有视网膜层面的CPD变化显著相关，包括浅表和深层血管丛以及视网膜血管网络（6mm扫描，r范围为0.58 - 0.83，P < 0.05）。浅表血管丛（6mm扫描）的RBF和CPD增加与连线测验A表现的改善（即时间缩短）相关（分别为r = -0.66，P < 0.01和r = -0.58，P < 0.05）。此外，视网膜血管网络中CPD的变化与霍普金斯词语延迟回忆的改善相关（r = 0.50，P < 0.05）。
这是第一项探索PD患者视网膜对瑜伽运动的微循环反应与认知功能之间关系的研究。CPD和RBF的协同效应可能发展成为监测PD患者瑜伽运动认知改善效果的眼部指标。
