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时间和州立法减少了美国择期足踝手术中的阿片类药物处方。

Time and State Legislation Have Decreased Opioid Prescribing in Elective Foot and Ankle Surgery in the United States.

作者信息

Cunningham Daniel J, Kwon Nicholas F, Allen Nicholas B, Hanselman Andrew M, Adams Samuel B

机构信息

Department of Orthopaedic Surgery, Duke University, Durham, North Carolina.

出版信息

Foot Ankle Spec. 2023 Oct;16(5):485-496. doi: 10.1177/19386400211043361. Epub 2021 Oct 6.

Abstract

BACKGROUND

Legislation in the United States has been enacted to reduce opioid overuse and abuse in the setting of the opioid epidemic, and a notable target has been opioid overprescription. However, the impact of this legislation on elective foot and ankle surgery is largely unknown. The purpose of this study was to evaluate the impact of opioid-limiting legislation on opioid prescribing in elective foot and ankle surgery.

METHODS

The 90-day perioperative opioid prescription filling in oxycodone 5-mg equivalents was identified in all patients 18 years of age and older undergoing nontrauma, nonarthroplasty foot and ankle surgery from 2010 to 2019 using a commercial database. States with and without legislation were identified, and opioid prescription filling before and after the legislation were tabulated. Unadjusted and adjusted analyses were performed to evaluate the impact of time and state legislation on perioperative opioid prescribing in this patient population.

RESULTS

Initial and cumulative opioid prescribing decreased significantly from 2010 to 2019 (39 vs 35.7 initial and 98.1 vs 55.7 cumulative). States with legislation had larger and more significant reductions in initial and cumulative opioid prescribing compared with states without legislation over similar time frames (41.6 to 35.1 with legislation vs 40.6 to 39.1 without legislation initial prescription filling volume and 87.7 to 62.8 vs 88.6 to 74.1 cumulative prescription filling volume).

CONCLUSION

State legislation and time have been associated with large, clinically relevant reductions in 90-day perioperative cumulative opioid prescription filling, although reductions in initial opioid prescription filing have remained low. These results encourage states without legislation to enact restraints to reduce the opioid epidemic.

LEVELS OF EVIDENCE

Level III: Retrospective, prognostic cohort study.

摘要

背景

美国已颁布立法以减少阿片类药物在阿片类药物流行背景下的过度使用和滥用,其中一个显著目标是阿片类药物的过度处方。然而,这项立法对择期足踝手术的影响在很大程度上尚不清楚。本研究的目的是评估阿片类药物限制立法对择期足踝手术中阿片类药物处方的影响。

方法

使用商业数据库确定了2010年至2019年期间所有18岁及以上接受非创伤性、非关节置换的足踝手术患者围手术期90天内按羟考酮5毫克当量计算的阿片类药物处方配药量。确定了有立法和无立法的州,并列出了立法前后的阿片类药物处方配药量。进行了未调整和调整分析,以评估时间和州立法对该患者群体围手术期阿片类药物处方的影响。

结果

2010年至2019年,初始和累积阿片类药物处方量显著下降(初始处方量从39降至35.7,累积处方量从98.1降至55.7)。与无立法的州相比,在类似的时间框架内,有立法的州初始和累积阿片类药物处方量的减少幅度更大且更显著(有立法的州初始处方配药量从41.6降至35.1,无立法的州从40.6降至39.1;累积处方配药量从87.7降至62.8,无立法的州从88.6降至74.1)。

结论

州立法和时间与90天围手术期累积阿片类药物处方配药量的大幅、具有临床意义的减少相关,尽管初始阿片类药物处方量的减少仍然较低。这些结果鼓励没有立法的州制定限制措施以减少阿片类药物流行。

证据级别

三级:回顾性、预后队列研究。

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