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择期足踝手术前的阿片类药物处方实践:基于加拿大一家三级医院的卫生行政数据的人群评估。

Opioid prescribing practices prior to elective foot and ankle surgery: a population-based evaluation using health administrative data from a tertiary hospital in Canada.

机构信息

Division of Orthopedic Surgery, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, T6G 2R3, Canada.

Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, 6-110 Clinical Sciences Building, Edmonton, T6G 2G4, Canada.

出版信息

BMC Prim Care. 2022 May 12;23(1):116. doi: 10.1186/s12875-022-01722-x.

Abstract

BACKGROUND

Complex elective foot and ankle surgery is known to be painful so most patients are prescribed opioids at the time of surgery; however, the number of patients prescribed opioids while waiting for surgery in Canada is unknown. Our primary objective was to describe the pre and postoperative prescribing practices for patients in Alberta, Canada undergoing complex elective foot and ankle surgery. Secondarily, we evaluated postoperative opioid usage and hospital outcomes.

METHODS

In this population-based retrospective analysis, we identified all adult patients who underwent unilateral elective orthopedic foot and ankle surgery at a single tertiary hospital between May 1, 2015 and May 31, 2017. Patient and surgical data were extracted from a retrospective chart review and merged with prospectively collected, individual level drug dispensing administrative data to analyze opioid dispensing patterns, including dose, duration, and prescriber for six months before and after foot and ankle surgery.

RESULTS

Of the 100 patients, 45 had at least one opioid prescription dispensed within six months before surgery, and of these, 19 were long-term opioid users (> 90 days of continuous use). Most opioid users obtained opioid prescriptions from family physicians both before (78%) and after (65%) surgery. No preoperative non-users transitioned to long-term opioid use postoperatively, but 68.4% of the preoperative long-term opioid users remained long-term opioid users postoperatively. During the index hospitalization, preoperative long-term opioid users consumed higher doses of opioids (99.7 ± 120.5 mg/day) compared to opioid naive patients (28.5 ± 36.1 mg/day) (p < 0.001). Long-term opioid users stayed one day longer in hospital than opioid-naive patients (3.9 ± 2.8 days vs 2.7 ± 1.1 days; p = 0.01).

CONCLUSIONS

A significant number of patients were dispensed opioids before and after foot and ankle surgery with the majority of prescriptions coming from primary care practitioners. Patients who were prescribed long-term opioids preoperatively were more likely to continue to use opioids at follow-up and required larger in-hospital opioid dosages and stayed longer in hospital. Further research and education for both patients and providers are needed to reduce the community-based prescribing of opioid medication pre-operatively and provide alternative pain management strategies prior to surgery to improve postoperative outcomes and reduce long-term postoperative opioid use.

摘要

背景

复杂的足部和踝关节择期手术是疼痛的,所以大多数患者在手术时都会开阿片类药物;然而,加拿大等待手术的患者开阿片类药物的数量尚不清楚。我们的主要目的是描述在加拿大艾伯塔省接受复杂足部和踝关节择期手术的患者的术前和术后处方情况。其次,我们评估了术后阿片类药物的使用情况和住院结果。

方法

在这项基于人群的回顾性分析中,我们确定了 2015 年 5 月 1 日至 2017 年 5 月 31 日期间在一家三级医院接受单侧择期骨科足部和踝关节手术的所有成年患者。从回顾性图表审查中提取患者和手术数据,并与前瞻性收集的个体水平药物配药行政数据合并,以分析 6 个月前和足部和踝关节手术后的阿片类药物配药模式,包括剂量、持续时间和处方医生。

结果

在 100 名患者中,有 45 名患者在手术前 6 个月内至少有一次阿片类药物处方,其中 19 名患者是长期阿片类药物使用者(连续使用超过 90 天)。大多数阿片类药物使用者在术前(78%)和术后(65%)都从家庭医生那里获得阿片类药物处方。没有术前非使用者术后转为长期阿片类药物使用者,但术前长期阿片类药物使用者中有 68.4%术后仍为长期阿片类药物使用者。在住院期间,术前长期阿片类药物使用者的阿片类药物用量(99.7±120.5mg/天)高于阿片类药物未使用者(28.5±36.1mg/天)(p<0.001)。长期阿片类药物使用者的住院时间比阿片类药物未使用者长一天(3.9±2.8 天比 2.7±1.1 天;p=0.01)。

结论

大量患者在足部和踝关节手术前后都开了阿片类药物,大多数处方都来自初级保健医生。术前开长期阿片类药物的患者在随访中更有可能继续使用阿片类药物,需要更大剂量的院内阿片类药物,并在医院停留更长时间。需要对患者和医务人员进行进一步的研究和教育,以减少术前社区开阿片类药物处方,并在手术前提供替代的疼痛管理策略,以改善术后结果和减少长期术后阿片类药物的使用。

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