University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
Cecil G. Sheps Center for Health Services Research, Chapel Hill, NC, USA.
Leuk Lymphoma. 2022 Feb;63(2):344-352. doi: 10.1080/10428194.2021.1984450. Epub 2021 Oct 6.
This study describes the prevalence and persistence of fatigue among a cohort of long-term non-Hodgkin lymphoma (NHL) survivors. Mailed surveys assessed quality-of-life including fatigue (SF-36) at baseline and five years. Logistic regression was used to identify factors associated with prevalence of fatigue at baseline and persistence of fatigue across timepoints. More than one-quarter (27.7%) of the 555 NHL survivors reported clinically meaningful fatigue at baseline and 18.7% reported persistent fatigue at five years. One-third (34.4%) reported clinically meaningful worsening of fatigue over time. Independent associations with persistent fatigue included female gender, less education, past chemotherapy, increased comorbidities, and posttraumatic stress symptoms ( <.05). Our findings suggest that one in three NHL survivors experience clinically meaningful fatigue long after their diagnosis and initial treatment. Furthermore, we found that fatigue worsens or persists for many, highlighting the need for vigilance in assessing and treating fatigue in this population.
本研究描述了队列中长期非霍奇金淋巴瘤 (NHL) 幸存者的疲劳发生率和持续性。通过邮寄调查评估了基线时和五年时的生活质量，包括疲劳 (SF-36)。使用逻辑回归来确定与基线时疲劳发生率以及随时间点疲劳持续性相关的因素。在 555 名 NHL 幸存者中，超过四分之一 (27.7%) 报告基线时存在临床意义上的疲劳，18.7% 报告五年时存在持续性疲劳。三分之一 (34.4%) 报告随着时间的推移，疲劳有临床意义的恶化。与持续性疲劳相关的独立因素包括女性、受教育程度较低、过去接受过化疗、合并症增加和创伤后应激症状 ( <.05)。我们的研究结果表明，三分之一的 NHL 幸存者在诊断和初始治疗后很长时间仍会经历有临床意义的疲劳。此外，我们发现许多患者的疲劳恶化或持续存在，这突出表明需要警惕评估和治疗该人群的疲劳。
