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Tissue eosinophils express the IL-33 receptor ST2 and type 2 cytokines in patients with eosinophilic esophagitis.

作者信息

Uchida Amiko M, Lenehan Patrick J, Vimalathas Praveen, Miller Kaia C, Valencia-Yang Mabel, Qiang Li, Canha Lauren A, Ali Lestat R, Dougan Michael, Garber John J, Dougan Stephanie K

机构信息

Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Department of Medicine, Harvard Medical School, Boston, MA, USA.

出版信息

Allergy. 2022 Feb;77(2):656-660. doi: 10.1111/all.15127. Epub 2021 Oct 11.

DOI:10.1111/all.15127
PMID:34614218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9052372/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/9292784/6f69477d238f/ALL-77-656-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/9292784/19032170d7f6/ALL-77-656-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/9292784/6f69477d238f/ALL-77-656-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/9292784/19032170d7f6/ALL-77-656-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1de/9292784/6f69477d238f/ALL-77-656-g001.jpg

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Tissue eosinophils express the IL-33 receptor ST2 and type 2 cytokines in patients with eosinophilic esophagitis.在嗜酸性食管炎患者中，组织嗜酸性粒细胞表达白细胞介素-33受体ST2和2型细胞因子。
Allergy. 2022 Feb;77(2):656-660. doi: 10.1111/all.15127. Epub 2021 Oct 11.
2
A novel IL-1 family cytokine, IL-33, potently activates human eosinophils.一种新型白细胞介素-1家族细胞因子白细胞介素-33能有效激活人嗜酸性粒细胞。
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Eosinophilic esophagitis: Shifting immune complexity beyond the eosinophil.嗜酸性粒细胞性食管炎：超越嗜酸性粒细胞的免疫复杂性转变
J Allergy Clin Immunol. 2024 Mar;153(3):669-671. doi: 10.1016/j.jaci.2024.01.007. Epub 2024 Jan 21.
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Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome.组织学嗜酸性胃炎是一种与血液和胃外嗜酸性粒细胞增多、TH2免疫及独特的胃转录组相关的全身性疾病。
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Eosinophils in obesity and obesity-associated disorders.

本文引用的文献

1
Eosinophils in Eosinophilic Esophagitis: The Road to Fibrostenosis is Paved With Good Intentions.嗜酸性粒细胞在嗜酸性粒细胞性食管炎中的作用：通向纤维狭窄的道路是善意铺就的。
Front Immunol. 2020 Dec 1;11:603295. doi: 10.3389/fimmu.2020.603295. eCollection 2020.
2
Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis.度普利尤单抗在成人活性嗜酸性粒细胞性食管炎的 2 期随机试验中的疗效。
Gastroenterology. 2020 Jan;158(1):111-122.e10. doi: 10.1053/j.gastro.2019.09.042. Epub 2019 Oct 5.
3
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
肥胖及肥胖相关疾病中的嗜酸性粒细胞。
Discov Immunol. 2023 Nov 14;2(1):kyad022. doi: 10.1093/discim/kyad022. eCollection 2023.
4
Eosinophilic esophagitis is associated with increased risk of later inflammatory bowel disease in a nationwide Swedish population cohort.嗜酸性粒细胞性食管炎与全国性瑞典人群队列中炎症性肠病的发病风险增加相关。
United European Gastroenterol J. 2024 Feb;12(1):34-43. doi: 10.1002/ueg2.12493. Epub 2023 Dec 7.
5
Recent Advances in the Treatment of Eosinophilic Esophagitis.嗜酸细胞性食管炎治疗的新进展。
J Allergy Clin Immunol Pract. 2023 Sep;11(9):2654-2663. doi: 10.1016/j.jaip.2023.06.035. Epub 2023 Jun 28.
6
Emerging Role of Alarmins in Food Allergy: An Update on Pathophysiological Insights, Potential Use as Disease Biomarkers, and Therapeutic Implications.警报素在食物过敏中的新作用：病理生理学见解、作为疾病生物标志物的潜在用途及治疗意义的最新进展
J Clin Med. 2023 Apr 4;12(7):2699. doi: 10.3390/jcm12072699.
7
Interleukin-33 Induces Neutrophil Extracellular Trap (NET) Formation and Macrophage Necroptosis via Enhancing Oxidative Stress and Secretion of Proatherogenic Factors in Advanced Atherosclerosis.白细胞介素-33通过增强晚期动脉粥样硬化中的氧化应激和促动脉粥样硬化因子分泌诱导中性粒细胞胞外陷阱（NET）形成和巨噬细胞坏死性凋亡。
Antioxidants (Basel). 2022 Nov 26;11(12):2343. doi: 10.3390/antiox11122343.
8
Human differentiated eosinophils release IL-13 in response to IL-33 stimulation.人源分化的嗜酸性粒细胞在受到 IL-33 刺激时会释放 IL-13。
Front Immunol. 2022 Sep 13;13:946643. doi: 10.3389/fimmu.2022.946643. eCollection 2022.
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Front Immunol. 2022 Jul 6;13:943518. doi: 10.3389/fimmu.2022.943518. eCollection 2022.
更新的嗜酸性粒细胞性食管炎国际共识诊断标准：AGREE 会议纪要。
Gastroenterology. 2018 Oct;155(4):1022-1033.e10. doi: 10.1053/j.gastro.2018.07.009. Epub 2018 Sep 6.
4
IL-33 is induced in undifferentiated, non-dividing esophageal epithelial cells in eosinophilic esophagitis.白细胞介素 33 在嗜酸性食管炎中未分化、非分裂的食管上皮细胞中诱导产生。
Sci Rep. 2017 Dec 14;7(1):17563. doi: 10.1038/s41598-017-17541-5.
5
Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice.白细胞介素-33表达升高与小儿嗜酸性粒细胞性食管炎相关，外源性白细胞介素-33可促进小鼠嗜酸性粒细胞性食管炎的发展。
Am J Physiol Gastrointest Liver Physiol. 2016 Jan 1;310(1):G13-25. doi: 10.1152/ajpgi.00290.2015. Epub 2015 Oct 29.
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Cytokine expression in healthy and inflamed mucosa: probing the role of eosinophils in the digestive tract.健康和炎症黏膜中的细胞因子表达：探究嗜酸性粒细胞在消化道中的作用
Inflamm Bowel Dis. 2005 Aug;11(8):720-6. doi: 10.1097/01.mib.0000172557.39767.53.