Dietz Andreas, Wichmann Gunnar, Wiegand Susanne
Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Plastische Operationen, Universität Leipzig, Leipzig, Germany.
Laryngorhinootologie. 2021 Oct;100(10):832-844. doi: 10.1055/a-1523-9045. Epub 2021 Oct 6.
Oropharynx carcinoma (OPSCC) is a genetically heterogeneous tumor group with high prognostic diversity due to its worldwide increase in incidence and the association with the human papillomavirus HPV 16, but also chronic tobacco/alcohol consumption.
The review attempts to present the current view on therapy and prevention of OPSCC with respect to association with HPV 16.
MATERIAL & METHODS: The overview is based on the current relevant literature as well as current studies.
RESULTS & DISCUSSION: The OPSCC presents itself as a very complex, genetically heterogeneous group of head and neck tumors, which should therefore be considered in detail. The currently contradictory trial situation of retrospective studies versus prospective trials, the current TNM classification (8th edition) and the scarce prospective data arguing for non-inferiority of therapy de-intensification attempts currently admonish to encourage a more conservative treatment.
口咽癌（OPSCC）是一组基因异质性肿瘤，由于其在全球范围内发病率上升，且与人乳头瘤病毒16型（HPV 16）相关，同时也与长期吸烟/饮酒有关，因此预后差异很大。
本综述试图阐述关于HPV 16与口咽癌治疗及预防相关性的当前观点。
本综述基于当前相关文献以及当前研究。
口咽癌表现为一组非常复杂的、基因异质性的头颈部肿瘤，因此应进行详细考虑。目前回顾性研究与前瞻性试验相互矛盾的试验情况、当前的TNM分类（第8版）以及支持治疗降强度尝试非劣效性的前瞻性数据稀缺，目前都告诫要鼓励采取更保守的治疗方法。
