Yun Chawon, Lee Hyun Jae, Lee Choong Jae
Department of Pharmacology, School of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea.
Smith Liberal Arts College and Department of Addiction Science, Graduate School, Sahmyook University, Seoul 01795, Republic of Korea.
Biomol Ther (Seoul). 2021 Nov 1;29(6):571-581. doi: 10.4062/biomolther.2021.134.
Towards the end of 2019, an atypical acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified in Wuhan, China and subsequently named Coronavirus disease 2019 (COVID-19). The rapid dissemination of COVID-19 has provoked a global crisis in public health. COVID-19 has been reported to cause sepsis, severe infections in the respiratory tract, multiple organ failure, and pulmonary fibrosis, all of which might induce mortality. Although several vaccines for COVID-19 are currently being administered worldwide, the COVID-19 pandemic is not yet effectively under control. Therefore, novel therapeutic agents to eradicate the cause of the disease and/or manage the clinical symptoms of COVID-19 should be developed to effectively regulate the current pandemic. In this review, we discuss the possibility of managing the clinical symptoms of COVID-19 using natural products derived from medicinal plants used for controlling pulmonary inflammatory diseases in folk medicine. Diverse natural products have been reported to exert potential antiviral effects by affecting viral replication, entry into host cells, assembly in host cells, and release. However, the antiviral effects and clinical antiviral efficacies of these natural products against SARS-CoV-2 have not been successfully proven to date. Thus, these properties need to be elucidated through further investigations, including randomized clinical trials, in order to develop optimal and ideal therapeutic candidates for COVID-19.
2019年底，中国武汉发现了一种由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的非典型急性呼吸道疾病，随后被命名为2019冠状病毒病（COVID-19）。COVID-19的迅速传播引发了一场全球公共卫生危机。据报道，COVID-19可导致败血症、呼吸道严重感染、多器官功能衰竭和肺纤维化，所有这些都可能导致死亡。尽管目前全球正在接种几种COVID-19疫苗，但COVID-19大流行尚未得到有效控制。因此，应开发新型治疗药物以根除疾病病因和/或控制COVID-19的临床症状，从而有效控制当前的大流行。在这篇综述中，我们讨论了使用民间医学中用于控制肺部炎症性疾病的药用植物衍生的天然产物来控制COVID-19临床症状的可能性。据报道，多种天然产物可通过影响病毒复制、进入宿主细胞、在宿主细胞中组装和释放来发挥潜在的抗病毒作用。然而，这些天然产物对SARS-CoV-2的抗病毒作用和临床抗病毒疗效迄今尚未得到成功证实。因此，需要通过包括随机临床试验在内的进一步研究来阐明这些特性，以便为COVID-19开发最佳和理想的治疗候选药物。
