Yoo Seung Ah, Park Hyo Eun, Kim Miri
Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ann Dermatol. 2021 Oct;33(5):467-469. doi: 10.5021/ad.2021.33.5.467. Epub 2021 Sep 8.
Bee-venom is composed of a variety of peptides, enzymes, and biogenic amines, and is demonstrated to have both antiinflammatory and immune-stimulatory effects in human body. Pemphigus foliaceus (PF) is a variant of pemphigus, which is a rare autoimmune bullous disease presenting with erythematous scaly crusted plaques. Although the exact pathogenesis was not identified, there have been three case reports of autoimmune disorders associated with bee-venom. In this case, a 64-year-old female was diagnosed with PF, which was developed after alternative bee-venom acupuncture therapy. We assumed that the bee-venom caused the diseases through a temporal relationship and its known immunostimulatory action. Herein, we suggest that physicians recognize the possibility of bee-venom stimulating the immune system and triggering various autoimmune diseases including pemphigus.
蜂毒由多种肽、酶和生物胺组成，且已证明其在人体中具有抗炎和免疫刺激作用。落叶型天疱疮（PF）是天疱疮的一种变体，天疱疮是一种罕见的自身免疫性大疱性疾病，表现为红斑鳞屑结痂斑块。尽管确切的发病机制尚未明确，但已有三例自身免疫性疾病与蜂毒相关的病例报告。在本病例中，一名64岁女性被诊断为PF，该病是在接受替代蜂毒针刺疗法后出现的。我们推测蜂毒通过时间关系及其已知的免疫刺激作用导致了这些疾病。在此，我们建议医生认识到蜂毒刺激免疫系统并引发包括天疱疮在内的各种自身免疫性疾病的可能性。
