我们能否通过肝移植来降低氧化应激？
Can we reduce oxidative stress with liver transplantation?
作者信息
Aydin Mesut, Dirik Yaren, Demir Canan, Tolunay Harun Egemen, Demir Halit
机构信息
Van Yuzuncu Yil University, Medical Faculty, Department of Gastroenterology, Van, Turkey.
Van Yuzuncu Yil University, Vocational School of Healthcare, Van, Turkey.
出版信息
J Med Biochem. 2021 Sep 3;40(4):351-357. doi: 10.5937/jomb0-29983.
BACKGROUND
The aim of this study was to determine the levels of lipid peroxidation (MDA) and antioxidants such as reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in the blood serum of patients with cirrhosis and liver transplantation.
METHODS
In this study, serum malondialdehyde acid (MDA) levels, superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) activities were measured spectrophotometrically and compared to the results of the healthy control group.
RESULTS
SOD, CAT and GSH activities were significantly decreased in the patient groups compared to the healthy control group (p<0.05). MDA levels were significantly higher in the patient group compared to the healthy control group (p <0.05).
CONCLUSIONS
In conclusion, this study demonstrated that oxidative stress may play an important role in the development of liver cirrhosis and in liver transplantation. This study is the first one to show how MDA, SOD, CAT and GSH levels change in liver cirrhosis and liver transplantation, while further studies are essential to investigate antioxidant enzymes and oxidative stress status in patients with cirrhosis and liver transplantation.
背景
本研究旨在测定肝硬化患者及肝移植患者血清中的脂质过氧化水平（丙二醛）以及抗氧化剂水平，如还原型谷胱甘肽（GSH）、过氧化氢酶（CAT）和超氧化物歧化酶（SOD）。
方法
在本研究中，采用分光光度法测定血清丙二醛酸（MDA）水平、超氧化物歧化酶（SOD）、还原型谷胱甘肽（GSH）和过氧化氢酶（CAT）活性，并与健康对照组的结果进行比较。
结果
与健康对照组相比，患者组的SOD、CAT和GSH活性显著降低（p<0.05）。与健康对照组相比，患者组的MDA水平显著升高（p<0.05）。
结论
总之，本研究表明氧化应激可能在肝硬化的发展及肝移植过程中起重要作用。本研究首次展示了肝硬化及肝移植患者中MDA、SOD、CAT和GSH水平的变化，而进一步研究对于调查肝硬化及肝移植患者的抗氧化酶和氧化应激状态至关重要。
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