Yamai Takuo, Ikezawa Kenji, Daiku Kazuma, Maeda Shingo, Abe Yutaro, Kai Yugo, Takada Ryoji, Nakabori Tasuku, Fukutake Nobuyasu, Uehara Hiroyuki, Masaie Hiroaki, Ishida Kaori, Kubo Chiaki, Ohkawa Kazuyoshi
Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan.
Department of Hematology, Osaka International Cancer Institute, Osaka, Japan.
Case Rep Gastroenterol. 2021 Jun 3;15(2):482-487. doi: 10.1159/000515570. eCollection 2021 May-Aug.
Primary pancreatic lymphomas (PPLs) are rare, and the histological classification of these tumors is difficult. To accurately diagnose and determine the appropriate treatment for PPLs, sufficient sample amounts are necessary. Here, we report a 73-year-old man with a primary pancreatic mantle cell lymphoma. Histological samples were obtained via endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The tumor cells predominantly composed of atypical small to medium round cells, with diffuse immunoreactivity of CD20 and cyclin D1. In addition, immunoglobulin gene H chain rearrangement was detected. The patient underwent chemotherapy, resulting in complete remission. Eight years after the initiation of chemotherapy, the patient was still alive. EUS-FNA could be a useful and safe diagnostic modality for PPLs by providing enough samples for testing.
原发性胰腺淋巴瘤（PPLs）较为罕见，且这些肿瘤的组织学分类颇具难度。为准确诊断并确定PPLs的恰当治疗方案，足够的样本量必不可少。在此，我们报告一例73岁男性原发性胰腺套细胞淋巴瘤患者。组织学样本通过超声内镜引导下细针穿刺抽吸术（EUS-FNA）获取。肿瘤细胞主要由非典型的小至中等大小圆形细胞组成，CD20和细胞周期蛋白D1呈弥漫性免疫反应。此外，检测到免疫球蛋白基因H链重排。该患者接受了化疗，实现完全缓解。化疗开始八年后，患者仍存活。EUS-FNA可为PPLs提供足够的检测样本，是一种有用且安全的诊断方式。
