Kim Seok Bae
Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea.
Case Rep Gastroenterol. 2021 Jul 8;15(2):610-615. doi: 10.1159/000514529. eCollection 2021 May-Aug.
There are only 13 cases of complete remission after sorafenib use in advanced hepatocellular carcinoma (HCC) worldwide. We herein report a rarer case in which the patient was cured after only 20 days of sorafenib use. A 61-year-old male patient was diagnosed with a huge HCC. The mass occupied almost the whole of the right hepatic lobe and a portion of segment 4. We performed extended right hepatectomy for cure. However, 3.5-cm-sized subcarinal lymph node metastasis was detected at 15 months after operation. We prescribed sorafenib 400 mg bid for palliative treatment. The patient had severe fever, pain, and blisters on the hands and feet, so the patient stopped taking it after 20 days. Subcarinal lymph node disappeared on chest computed tomography after 3 months, and there was no evidence of recurrence for a year.
全球范围内，索拉非尼用于晚期肝细胞癌（HCC）治疗后仅有13例完全缓解的病例。我们在此报告1例更为罕见的病例，该患者仅使用索拉非尼20天后即获治愈。一名61岁男性患者被诊断为巨大型HCC。肿块几乎占据了整个右肝叶及第4段的一部分。我们实施了扩大右肝切除术以寻求治愈。然而，术后15个月发现3.5厘米大小的隆突下淋巴结转移。我们给予索拉非尼400毫克每日两次进行姑息治疗。患者出现高热、疼痛以及手脚水泡，因此在20天后停药。3个月后胸部计算机断层扫描显示隆突下淋巴结消失，且1年内无复发迹象。
