Li Yan, Zhang Lijia, Gao Jinjin, Yan Jun, Feng Xue, He Xiting, Jin Hong, Li Xinyu, Cui Zhengyi, Zhao Junfei, Liu Fengyi, Liu Xiaowai, Liu Yongfei, Ren Wan, Liu Songjiang
First Affiliated Hospital, Heilongjiang University of Chinese Medicine, 26 Heping Road, Harbin 150040, China.
Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin 150040, China.
Evid Based Complement Alternat Med. 2021 Sep 24;2021:5595478. doi: 10.1155/2021/5595478. eCollection 2021.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. As a widely used complementary and alternative therapy, acupuncture is increasingly used to treat PCOS. However, the effect of acupuncture in treating PCOS is uncertain, and the mechanisms are unclear. This systematic review aims to determine the efficacy of acupuncture on PCOS in animal preclinical models.
Experimental animal studies of acupuncture in PCOS animal models were searched in PubMed, Web of Science, China National Knowledge Infrastructure, and the Chinese Science and Technology Periodical Database from inception to December 2020. The risk of bias was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias tool.
A total of 358 studies were screened based on the title and abstract, and 31 studies were included. A total of 722 animals were involved, and all studies used either Wistar rats or SD rats. Twenty-six studies used electroacupuncture, 9 studies used manual acupuncture, and 5 of them employed both electroacupuncture and manual acupuncture. A total of 22 acupoints were involved; 7 studies followed the modern acupuncture pattern, and the rest followed classic acupuncture theory.
The present review summarizes the current evidence of the effects of acupuncture on PCOS in animal models. Unfortunately, we could not draw a definite conclusion due to the methodological weakness of the included studies and the high heterogeneity. Well-designed studies are needed in the future to fill this gap.
多囊卵巢综合征（PCOS）是育龄女性中最常见的内分泌疾病之一。作为一种广泛应用的补充和替代疗法，针灸越来越多地用于治疗PCOS。然而，针灸治疗PCOS的效果尚不确定，其机制也不清楚。本系统评价旨在确定针灸在动物临床前模型中治疗PCOS的疗效。
检索了PubMed、Web of Science、中国知网和中国科技期刊数据库中从创刊至2020年12月关于针灸治疗PCOS动物模型的实验动物研究。使用实验动物实验系统评价中心（SYRCLE）偏倚风险工具评估偏倚风险。
根据标题和摘要共筛选出358项研究，纳入31项研究。共涉及722只动物，所有研究均使用Wistar大鼠或SD大鼠。26项研究使用电针，9项研究使用手针，其中5项同时使用电针和手针。共涉及22个穴位；7项研究遵循现代针灸模式，其余遵循经典针灸理论。
本综述总结了目前针灸对动物模型中PCOS影响的证据。遗憾的是，由于纳入研究的方法学缺陷和高度异质性，我们无法得出明确结论。未来需要设计良好的研究来填补这一空白。
