Adamopoulos D A, Lawrence D M, Vassilopoulos P, Contoyiannis P A, Swyer G I
Br Med J. 1978 May 6;1(6121):1177-80. doi: 10.1136/bmj.1.6121.1177.
Leydig-cell function was assessed in 27 men with acute mumps orchitis by measuring plasma testosterone concentrations before and after the administration of human chorionic gonadotrophin (HCG). The test was also performed on groups of patients with other febrile viral infections and mumps without orchitis and on healthy euspermic men. The concentrations both before and after HCG were significantly lower in patients in the acute phase of mumps-but not in those with other viral infections and mumps without orchitis-than in the healthy men. Basal concentrations of follicle-stimulating hormone (FSH) and luteinising hormone (LH) were significantly increased in patients with acute mumps orchitis, while an exaggerated response to LH-releasing hormone was noted in four patients after the acute phase of the disease. Raised plasma LH concentrations were also found in several patients with viral infections, including mumps without orchitis. There appeared to be no particular merit of any of the treatments used (aspirin, prednisolone, and cold baths). In patients reevaluated three to five and 10 to 12 months after the acute phase of their disease the basal testosterone concentrations were similar to those of the healthy men, but several of the patients showed a severely impaired response to HCG. Mean basal FSH and LH concentrations were significantly increased 10 to 12 months after the acute phase, while the mean LH concentration was also raised at three to five months.It is concluded that mumps orchitis impairs Leydigcell function during the acute phase of the disease but may also have a more permanent damaging effect, similar to that found in the germinal epithelium.
通过测量27例急性流行性腮腺炎睾丸炎患者在注射人绒毛膜促性腺激素（HCG）前后的血浆睾酮浓度，对其睾丸间质细胞功能进行评估。该测试也在患有其他发热性病毒感染的患者组、患腮腺炎但无睾丸炎的患者组以及健康的正常精子男性中进行。与健康男性相比，流行性腮腺炎急性期患者在注射HCG前后的浓度均显著降低，但其他病毒感染患者和患腮腺炎但无睾丸炎的患者则不然。急性流行性腮腺炎睾丸炎患者的基础促卵泡激素（FSH）和促黄体生成素（LH）浓度显著升高，而在疾病急性期过后，有4例患者对促黄体生成素释放激素的反应过度。在包括患腮腺炎但无睾丸炎的几名病毒感染患者中也发现血浆LH浓度升高。所使用的任何治疗方法（阿司匹林、泼尼松龙和冷水浴）似乎都没有特别的效果。在疾病急性期过后3至5个月以及10至12个月重新评估的患者中，基础睾酮浓度与健康男性相似，但有几名患者对HCG的反应严重受损。急性期过后10至12个月，平均基础FSH和LH浓度显著升高，而在3至5个月时平均LH浓度也升高。结论是，流行性腮腺炎睾丸炎在疾病急性期会损害睾丸间质细胞功能，但也可能产生更持久的损害作用，类似于生精上皮中发现的情况。
