Narkar Akshay, Johnson Blake A, Li Rong
Center for Cell Dynamics and Department of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mol Cell Oncol. 2021 Jun 28;8(4):1938479. doi: 10.1080/23723556.2021.1938479. eCollection 2021.
TP53-dependent cell cycle arrest has been proposed to limit the proliferation of aneuploid cells. We investigated the cellular response to aneuploidy in cell lines and organoid cultures and found that TP53 (also known as p53) is not activated following aneuploidy induction in organoids. However, we confirmed that p53 is required for high mitotic fidelity. Our findings provide a revised view on how p53 safeguards against aneuploidy.
有人提出，依赖TP53的细胞周期阻滞可限制非整倍体细胞的增殖。我们研究了细胞系和类器官培养物对非整倍体的细胞反应，发现类器官中诱导非整倍体后TP53（也称为p53）未被激活。然而，我们证实p53是高有丝分裂保真度所必需的。我们的研究结果为p53如何防止非整倍体提供了一个新的观点。
