Department of Chemistry, Fudan University, Shanghai 200438, P. R. China.
School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, P. R. China.
J Mater Chem B. 2021 Oct 27;9(41):8686-8693. doi: 10.1039/d1tb01628h.
Short peptides with self-assembled nanostructures are widely applied in the areas of drug delivery systems and biomaterials. In this article, we create a new peptide-based hydrogelator (Fmoc-FFRRVR) based on -fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) through an approach to improve its hydrophilicity. Compared to Fmoc-FF, Fmoc-FFRRVR prefers to form a hydrogel under mild conditions, and the gelation time is only 2 s. Fmoc-FFRRVR self-assembles into organized arrays of β-sheets in nanofibers π-stacking of Fmoc-FF, which are supported by circular dichroism and fluorescence emission spectroscopy. Rheology results confirm that the hydrogel of Fmoc-FFRRVR is elastic, reversible and injectable. The newly discovered hydrogel not only retains some excellent performances of Fmoc-FF, but also can be used as a drug carrier for biomedical applications.
具有自组装纳米结构的短肽在药物传递系统和生物材料领域得到了广泛应用。在本文中，我们通过提高亲水性的方法，基于 - 芴甲氧羰基 - 二苯丙氨酸（Fmoc-FF）合成了一种新的基于肽的水凝胶因子（Fmoc-FFRRVR）。与 Fmoc-FF 相比，Fmoc-FFRRVR 更喜欢在温和条件下形成水凝胶，凝胶时间仅为 2 秒。Fmoc-FFRRVR 自组装成纳米纤维中的 β- 折叠有序排列，通过圆二色性和荧光发射光谱证实了 Fmoc-FF 的 π- 堆积。流变学结果证实 Fmoc-FFRRVR 的水凝胶具有弹性、可逆性和可注射性。新发现的水凝胶不仅保留了 Fmoc-FF 的一些优异性能，而且可用作生物医学应用的药物载体。
