Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Bull Exp Biol Med. 2021 Sep;171(5):592-595. doi: 10.1007/s10517-021-05275-4. Epub 2021 Oct 7.
The content of carbonyl compounds (methylglyoxal and TBA-reactive substances) and components of the glutathione system (activities of glutathione-dependent enzymes, content of oxidized and reduced glutathione) and their interrelationships were studied in men of young reproductive age with type 1 diabetes mellitus at the stages of normo- and microalbuminuria. In patients with normoalbuminuria, the level of methylglyoxal, reduced and oxidized glutathione, and glutathione reductase activity were increased and the content of TBA-reactive substances was decreased. In the group with microalbuminuria, an increase in content of methylglyoxal and activity of glutathione-dependent enzymes relative to the control values were observed; the content of TBA-reactive substances was increased and glutathione reductase activity was decreased relative to the group with normoalbuminuria. In patients with microalbuminuria, a strong correlation between the mean glomerular filtration rate and the blood level of methylglyoxal was revealed.
研究了青年生育期 1 型糖尿病患者在正常和微量白蛋白尿阶段羰基化合物（甲基乙二醛和 TBA 反应物质）和谷胱甘肽系统成分（谷胱甘肽依赖酶的活性、氧化和还原型谷胱甘肽的含量）及其相互关系。在正常白蛋白尿患者中，甲基乙二醛、还原型和氧化型谷胱甘肽以及谷胱甘肽还原酶活性增加，TBA 反应物质含量降低。在微量白蛋白尿组中，与对照组相比，观察到甲基乙二醛含量和谷胱甘肽依赖酶活性增加；TBA 反应物质含量增加，谷胱甘肽还原酶活性降低。在微量白蛋白尿患者中，揭示了平均肾小球滤过率与血液中甲基乙二醛水平之间的强相关性。
