Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.
Chem Rec. 2021 Dec;21(12):4015-4031. doi: 10.1002/tcr.202100231. Epub 2021 Oct 7.
The construction of carbon-fluorine bonds is an important yet challenging task in organic synthesis. Transition metal-catalyzed/-mediated C-F bond forming processes have recently emerged as a viable strategy and provided access to value-added monofluorinated compounds. A dramatic increase in fluorination methods using inexpensive and earth-abundant copper can be seen in the past decade surpassing those using palladium and silver. This review discusses the recent development of Cu-catalyzed/-mediated formation of C(sp )-F and C(sp )-F bonds.
碳-氟键的构建是有机合成中的一项重要而具有挑战性的任务。近年来，过渡金属催化/介导的 C-F 键形成过程已经成为一种可行的策略，为有价值的单氟化化合物提供了途径。在过去的十年中，使用廉价且丰富的铜的氟化方法急剧增加，超过了使用钯和银的方法。本文综述了近年来 Cu 催化/介导的 C(sp )-F 和 C(sp )-F 键形成的发展。
