Abe R, Umezu H, Uchida T, Kariyone S, Maseki N, Kaneko Y, Sakurai M
Cancer. 1986 Sep 15;58(6):1260-4. doi: 10.1002/1097-0142(19860915)58:6<1260::aid-cncr2820580614>3.0.co;2-o.
An 8;21 chromosome translocation was found in cells from myeloblastomas of two acute myeloblastic leukemia (AML) patients. In one patient, a sudden onset of paraplegia, which was caused by an epidural myeloblastoma in the thoracic vertebral canal, was the initial symptom of the disease and that of the first relapse. In the other, myeloblastomas, which occurred in the breasts during a hematologic remission, heralded the first relapse. Karyotypes of tumor cells obtained from both patients showed the t(8;21) and additional chromosome abnormalities. These findings, together with earlier experience and reports in the literature, indicate that myeloblastoma may be unique to the 8;21 translocation, and that certain chromosomal abnormalities additional to the t(8;21) may be necessary for the tumor formation.
在两名急性髓细胞白血病（AML）患者的成髓细胞瘤细胞中发现了8号与21号染色体易位。其中一名患者，由胸椎椎管内硬膜外成髓细胞瘤引起的截瘫突然发作，是该疾病的初始症状以及首次复发的症状。另一名患者，在血液学缓解期乳房出现成髓细胞瘤，预示着首次复发。从两名患者获得的肿瘤细胞的核型均显示t(8;21)以及其他染色体异常。这些发现，连同早期的经验和文献报道，表明成髓细胞瘤可能是8;21易位所特有的，并且除了t(8;21)之外的某些染色体异常对于肿瘤形成可能是必要的。
