伴有表型差异演变的急性髓细胞白血病中的变异易位t(8;21;15)

Variant translocation t(8;21;15) in an acute myeloblastic leukemia with phenotypic differential evolution.

作者信息

Ayraud N, Raynaud S, Bayle J, Dujardin P

出版信息

Cancer Genet Cytogenet. 1985 Feb 15;15(3-4):191-7. doi: 10.1016/0165-4608(85)90162-1.

Abstract

A new case of a variant form of the translocation (8;21) in an AML-M2, including in addition involvement of chromosome #15 is reported. The selection of two abnormal lines, probably resulting from two successive rearrangements of the (8;15) translocated segment, is observed. It is suggested that these rearrangements change the cellular morphology and seem to play a part similar to additional autosomal abnormalities in the course of the disease, such as those found in CML.

摘要

报告了1例急性髓系白血病M2型（AML-M2）中易位（8；21）变异型的新病例，此外还涉及15号染色体。观察到选择了两条异常谱系，可能是（8；15）易位片段两次连续重排的结果。提示这些重排改变了细胞形态，并且在疾病过程中似乎发挥了与其他常染色体异常类似的作用，例如在慢性粒细胞白血病（CML）中发现的异常。