Lu Yun, Jiao Yixin, Graham David J, Wu Yue, Wang Jing, Menis Mikhail, Chillarige Yoganand, Wernecke Michael, Kelman Jeffrey, Forshee Richard A, Izurieta Hector S
Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Acumen LLC, Burlingame, California, USA.
J Infect Dis. 2022 Feb 15;225(4):567-577. doi: 10.1093/infdis/jiab515.
We evaluated prevaccine pandemic period COVID-19 death risk factors among nursing home (NH) residents.
In a retrospective cohort study covering Medicare fee-for-service beneficiaries aged ≥65 years residing in US NHs, we estimated adjusted hazard ratios (HRs) using multivariate Cox proportional hazards regressions.
Among 608251 elderly NH residents, 57398 (9.4%) died of COVID-19-related illness 1 April to 22 December 2020; 46.9% (26893) of these deaths occurred without prior COVID-19 hospitalizations. We observed a consistently increasing age trend for COVID-19 deaths. Racial/ethnic minorities shared similarly high risk of NH COVID-19 deaths with whites. NH facility characteristics for-profit ownership and low health inspection ratings were associated with higher death risk. Resident characteristics (male [HR, 1.69], end-stage renal disease [HR, 1.42], cognitive impairment [HR, 1.34], and immunocompromised status [HR, 1.20]) were death risk factors. Other individual-level characteristics were less predictive of death than in community-dwelling population.
Low NH health inspection ratings and private ownership contributed to COVID-19 death risks. Nearly half of NH COVID-19 deaths occurred without prior COVID-19 hospitalization and older residents were less likely to get hospitalized with COVID-19. No substantial differences were observed by race/ethnicity and socioeconomic status for NH COVID-19 deaths.
我们评估了养老院(NH)居民在疫苗接种前大流行期间的新冠病毒疾病死亡风险因素。
在一项回顾性队列研究中,纳入年龄≥65岁、居住在美国养老院且享受医疗保险按服务收费的受益人,我们使用多变量Cox比例风险回归估计调整后的风险比(HR)。
在608251名老年养老院居民中,57398人(9.4%)在2020年4月1日至12月22日期间死于新冠病毒相关疾病;其中46.9%(26893例)死亡病例此前未因新冠病毒住院治疗。我们观察到新冠病毒死亡病例的年龄趋势持续上升。少数族裔与白人在养老院新冠病毒死亡病例中的风险同样高。养老院的营利性所有权和健康检查评级低等特征与更高的死亡风险相关。居民特征(男性[HR,1.69]、终末期肾病[HR,1.42]、认知障碍[HR,1.34]和免疫功能低下状态[HR,1.20])是死亡风险因素。与社区居住人群相比,其他个体层面的特征对死亡的预测性较低。
养老院健康检查评级低和私立所有权导致了新冠病毒死亡风险。近一半的养老院新冠病毒死亡病例此前未因新冠病毒住院,且老年居民感染新冠病毒后住院的可能性较小。在养老院新冠病毒死亡病例中,未观察到种族/民族和社会经济地位方面的实质性差异。