School of Public and Population Health, University of Texas Medical Branch, Galveston, Texas, USA.
Sealy Center on Aging, University of Texas Medical Branch, Galveston, Texas, USA.
J Am Geriatr Soc. 2023 Jan;71(1):167-177. doi: 10.1111/jgs.18062. Epub 2022 Sep 22.
Psychiatric illness may pose an additional risk of death for older adults during the COVID-19 pandemic. Older adults in the community versus institutions might be influenced by the pandemic differently. This study examines excess deaths during the COVID-19 pandemic among Medicare beneficiaries with and without psychiatric diagnoses (depression, anxiety, bipolar disorder, and schizophrenia) in the community versus nursing homes.
This is a retrospective cohort study of a 20% random sample of 15,229,713 fee-for-service Medicare beneficiaries, from January 2019 through December 2021. Unadjusted monthly mortality risks, COVID-19 infection rates, and case-fatality rates after COVID-19 diagnosis were calculated. Excess deaths in 2020, compared to 2019 were estimated from multivariable logistic regressions.
Of all included Medicare beneficiaries in 2020 (N = 5,140,619), 28.9% had a psychiatric diagnosis; 1.7% lived in nursing homes. In 2020, there were 246,422 observed deaths, compared to 215,264 expected, representing a 14.5% increase over expected. Patients with psychiatric diagnoses had more excess deaths than those without psychiatric diagnoses (1,107 vs. 403 excess deaths per 100,000 beneficiaries, p < 0.01). The largest increases in mortality risks were observed among patients with schizophrenia (32.4% increase) and bipolar disorder (25.4% increase). The pandemic-associated increase in deaths with psychiatric diagnoses was only found in the community, not in nursing homes. The increased mortality for patients with psychiatric diagnoses was limited to those with medical comorbidities. The increase in mortality for psychiatric diagnoses was associated with higher COVID-19 infection rates (1-year infection rate = 7.9% vs. 4.2% in 2020), rather than excess case fatality.
Excess deaths during the COVID-19 pandemic were disproportionally greater in beneficiaries with psychiatric diagnoses, at least in part due to higher infection rates. Policy interventions should focus on preventing COVID-19 infections and deaths among community-dwelling patients with major psychiatric disorders in addition to those living the nursing homes.
精神疾病可能会使 COVID-19 大流行期间的老年患者面临更高的死亡风险。社区中的老年人和机构中的老年人可能会受到不同的大流行影响。本研究调查了社区而非疗养院中患有和不患有精神疾病(抑郁症、焦虑症、双相情感障碍和精神分裂症)的医疗保险受益人的 COVID-19 大流行期间的超额死亡人数。
这是一项回顾性队列研究,对 2019 年 1 月至 2021 年 12 月期间 15229713 名医疗保险费自理受益人的 20%随机样本进行研究。计算了未经调整的每月死亡率风险、COVID-19 感染率以及 COVID-19 诊断后的病例死亡率。使用多变量逻辑回归估计了 2020 年与 2019 年相比的超额死亡人数。
在 2020 年所有纳入的医疗保险受益人中(N=5140619),28.9%患有精神疾病;1.7%居住在疗养院中。2020 年,观察到的死亡人数为 246422 人,而预期死亡人数为 215264 人,与预期相比增加了 14.5%。患有精神疾病的患者比没有精神疾病的患者有更多的超额死亡人数(每 100000 名受益人中有 1107 人比 403 人超额死亡,p<0.01)。精神疾病患者的死亡率风险增加最大,其中精神分裂症患者增加了 32.4%,双相情感障碍患者增加了 25.4%。只有在社区中观察到与精神疾病相关的死亡人数增加,而在疗养院中没有观察到这种增加。患有精神疾病的患者的死亡率增加仅限于有合并症的患者。精神疾病诊断的死亡率增加与更高的 COVID-19 感染率相关(2020 年的 1 年感染率为 7.9%,而 2019 年为 4.2%),而不是超额病死率。
在 COVID-19 大流行期间,患有精神疾病的医疗保险受益人中的超额死亡人数不成比例地增加,至少部分原因是感染率较高。政策干预应侧重于预防社区居住的有严重精神疾病的患者以及居住在疗养院中的患者的 COVID-19 感染和死亡。