• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

去分化脂肪肉瘤中低级和高级去分化的急剧转变:一例罕见病例报告。

Dedifferentiated liposarcoma with abrupt transition of low-grade and high-grade dedifferentiation: A rare case report.

机构信息

Departments of Radiology, 74678Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

Departments of Pathology, 74678Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.

出版信息

Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211048565. doi: 10.1177/20587384211048565.

DOI:10.1177/20587384211048565
PMID:34620001
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8504230/
Abstract

Dedifferentiated liposarcoma is a unique subtype of liposarcoma, which has obvious histological heterogeneity. In affected patients, the condition typically manifests as the dedifferentiation of high-grade histological morphology, but it may also manifest as the dedifferentiation of low-grade histological morphology. In some cases, unique histological or immunophenotypic characteristics are observed. We describe, herein, a rare case of dedifferentiated liposarcoma, in which the high-grade and low-grade dedifferentiated components coexisted with a relatively sharp transition in pathology.

摘要

去分化脂肪肉瘤是一种独特的脂肪肉瘤亚型,具有明显的组织学异质性。在受影响的患者中,该疾病通常表现为高级别组织形态学的去分化,但也可能表现为低级别组织形态学的去分化。在某些情况下,还观察到独特的组织学或免疫表型特征。我们在此描述了一例罕见的去分化脂肪肉瘤病例,其中高级别和低级别去分化成分共存,病理学上具有相对明显的过渡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be2/8504230/dea54ef7fdf2/10.1177_20587384211048565-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be2/8504230/d636d85d7140/10.1177_20587384211048565-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be2/8504230/147c5270556f/10.1177_20587384211048565-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be2/8504230/6e9eb6f57027/10.1177_20587384211048565-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be2/8504230/dea54ef7fdf2/10.1177_20587384211048565-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be2/8504230/d636d85d7140/10.1177_20587384211048565-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be2/8504230/147c5270556f/10.1177_20587384211048565-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be2/8504230/6e9eb6f57027/10.1177_20587384211048565-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8be2/8504230/dea54ef7fdf2/10.1177_20587384211048565-fig4.jpg

相似文献

1
Dedifferentiated liposarcoma with abrupt transition of low-grade and high-grade dedifferentiation: A rare case report.去分化脂肪肉瘤中低级和高级去分化的急剧转变:一例罕见病例报告。
Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211048565. doi: 10.1177/20587384211048565.
2
Intraperitoneal dedifferentiated liposarcoma showing MDM2 amplification: case report.腹腔内去分化脂肪肉瘤伴 MDM2 扩增:病例报告。
World J Surg Oncol. 2013 Nov 26;11:305. doi: 10.1186/1477-7819-11-305.
3
Prognostic relevance of Fédération Nationale des Centres de Lutte Contre le Cancer grade and MDM2 amplification levels in dedifferentiated liposarcoma: a study of 50 cases.法国国立癌症中心分级及MDM2扩增水平在去分化脂肪肉瘤中的预后相关性:一项50例病例的研究
Mod Pathol. 2015 Jan;28(1):37-47. doi: 10.1038/modpathol.2014.88. Epub 2014 Jul 25.
4
Correlation of histological grade of dedifferentiation with clinical outcome in 55 patients with dedifferentiated liposarcomas.55例去分化脂肪肉瘤患者去分化组织学分级与临床结局的相关性
Hum Pathol. 2017 Aug;66:86-92. doi: 10.1016/j.humpath.2017.02.015. Epub 2017 Mar 12.
5
[Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features: a clinicopathological analysis of five cases].[具有炎性肌纤维母细胞瘤样特征的去分化脂肪肉瘤:5例临床病理分析]
Zhonghua Bing Li Xue Za Zhi. 2019 Apr 8;48(4):282-287. doi: 10.3760/cma.j.issn.0529-5807.2019.04.004.
6
Mosaic-pattern dedifferentiation in liposarcoma and chondrosarcoma: imaging features of an uncommon form of dedifferentiation.脂肪肉瘤和软骨肉瘤中的镶嵌式去分化:一种罕见去分化形式的影像学特征
Skeletal Radiol. 2018 Jun;47(6):877-882. doi: 10.1007/s00256-017-2866-4. Epub 2018 Jan 23.
7
Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria.去分化脂肪肉瘤伴“同源性”脂肪母细胞分化(多形性脂肪肉瘤样):一系列提示修订诊断标准的临床病理和分子分析。
Am J Surg Pathol. 2010 Aug;34(8):1122-31. doi: 10.1097/PAS.0b013e3181e5dc49.
8
Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma.MDM2/HMGA2 比值和组织学肿瘤分级对去分化脂肪肉瘤的预后意义。
Genes Chromosomes Cancer. 2021 Jan;60(1):26-37. doi: 10.1002/gcc.22899. Epub 2020 Oct 28.
9
Paratesticular dedifferentiated liposarcoma with prominent myxoid stroma: report of a case and review of the literature.伴有显著黏液样间质的睾丸旁去分化脂肪肉瘤:1例报告并文献复习
Med Mol Morphol. 2017 Jun;50(2):112-116. doi: 10.1007/s00795-015-0108-1. Epub 2015 May 19.
10
Dedifferentiated liposarcoma of the retro-peritoneum: histologically low-grade type.腹膜后去分化脂肪肉瘤:组织学低级别型
Indian J Pathol Microbiol. 2010 Apr-Jun;53(2):353-5. doi: 10.4103/0377-4929.64347.

引用本文的文献

1
Surgical Management of Retroperitoneal Liposarcoma: Opportunities for Multimodality Treatment, Including Systemic Therapy.腹膜后脂肪肉瘤的外科治疗:多模式治疗的机会,包括全身治疗。
Cancer Med. 2025 Aug;14(15):e71129. doi: 10.1002/cam4.71129.
2
Imaging and histopathological considerations in determining the primary site and differential diagnosis of gallbladder liposarcoma.确定胆囊脂肪肉瘤原发部位及鉴别诊断时的影像学和组织病理学考量
World J Surg Oncol. 2025 Jul 1;23(1):256. doi: 10.1186/s12957-025-03915-x.
3
Real-world survival outcomes and MDM2 prevalence in US patients with metastatic dedifferentiated liposarcoma.

本文引用的文献

1
A Proposed Staging System for Improved Prognostication of MDM2-amplified Liposarcoma.一种改良的 MDM2 扩增型脂肪肉瘤预后分期系统的提出。
Am J Surg Pathol. 2021 Jan;45(1):101-107. doi: 10.1097/PAS.0000000000001554.
2
Primary gastrointestinal liposarcoma-a clinicopathological study of 8 cases of a rare entity.原发性胃肠道脂肪肉瘤——一种罕见实体的临床病理研究。8 例报告。
Hum Pathol. 2020 Mar;97:80-93. doi: 10.1016/j.humpath.2019.12.004. Epub 2019 Dec 26.
3
[Updates on histologic diagnosis and differential diagnosis of dedifferentiated liposarcoma].
美国转移性去分化脂肪肉瘤患者的真实世界生存结果及MDM2患病率
Future Oncol. 2025 Jun;21(14):1797-1807. doi: 10.1080/14796694.2025.2502319. Epub 2025 Jun 4.
4
Dedifferentiated Liposarcoma of the Parotid Gland: A Rare Presentation.腮腺去分化脂肪肉瘤:一种罕见的表现。
Indian J Otolaryngol Head Neck Surg. 2025 Feb;77(2):1019-1022. doi: 10.1007/s12070-024-05239-w. Epub 2024 Nov 29.
5
Unmasking the Masquerade: Fine-Needle Aspiration Diagnosis of Dedifferentiated Liposarcoma Clinically Mimicking Lymphoma.揭开伪装:细针穿刺抽吸诊断临床疑似淋巴瘤的去分化脂肪肉瘤
Cureus. 2024 Mar 7;16(3):e55759. doi: 10.7759/cureus.55759. eCollection 2024 Mar.
6
The Immune Contexture of Liposarcoma and Its Clinical Implications.脂肪肉瘤的免疫微环境及其临床意义。
Cancers (Basel). 2022 Sep 21;14(19):4578. doi: 10.3390/cancers14194578.
[去分化脂肪肉瘤的组织学诊断与鉴别诊断进展]
Zhonghua Bing Li Xue Za Zhi. 2019 Jul 8;48(7):573-579. doi: 10.3760/cma.j.issn.0529-5807.2019.07.018.
4
Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.高分化脂肪肉瘤和去分化脂肪肉瘤:最新综述。
Semin Diagn Pathol. 2019 Mar;36(2):112-121. doi: 10.1053/j.semdp.2019.02.006. Epub 2019 Feb 28.
5
Dedifferentiated Liposarcoma: Updates on Morphology, Genetics, and Therapeutic Strategies.去分化脂肪肉瘤:形态学、遗传学及治疗策略的最新进展
Adv Anat Pathol. 2016 Jan;23(1):30-40. doi: 10.1097/PAP.0000000000000101.
6
Myogenic differentiation and histologic grading are major prognostic determinants in retroperitoneal liposarcoma.肌源性分化和组织学分级是腹膜后脂肪肉瘤主要的预后决定因素。
Am J Surg Pathol. 2015 Mar;39(3):383-93. doi: 10.1097/PAS.0000000000000366.
7
Lessons learned from the study of 10,000 patients with soft tissue sarcoma.从对10000例软组织肉瘤患者的研究中吸取的经验教训。
Ann Surg. 2014 Sep;260(3):416-21; discussion 421-2. doi: 10.1097/SLA.0000000000000869.
8
[New WHO classification of tumours of soft tissue and bone].[世界卫生组织软组织和骨肿瘤新分类]
Ann Pathol. 2012 Nov;32(5 Suppl):S115-6. doi: 10.1016/j.annpat.2012.07.006. Epub 2012 Oct 12.
9
Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms.采用荧光原位杂交技术检测MDM2基因扩增作为脂肪性肿瘤的诊断工具
Mod Pathol. 2008 Aug;21(8):943-9. doi: 10.1038/modpathol.2008.84. Epub 2008 May 23.
10
Diagnosis and management of lipomatous tumors.脂肪瘤性肿瘤的诊断与管理
J Surg Oncol. 2008 Mar 15;97(4):298-313. doi: 10.1002/jso.20975.