Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Clin Transl Gastroenterol. 2021 Oct 8;12(10):e00394. doi: 10.14309/ctg.0000000000000394.
Studies on eosinophilic gastroenteritis have identified broad spectrums of disease. We aimed to characterize subtypes of disease and ascertain outcomes of each group.
This is a retrospective cohort study from a large tertiary medical center including 35 patients diagnosed with eosinophilic gastroenteritis from 2007 to 2018. We defined 2 groups of patients based on clinical and laboratory findings at presentation. Severe disease was defined as having weight loss at time of presentation, hypoalbuminemia at presentation, serosal disease involvement, or anemia at diagnosis. The remaining patients were labeled as mild disease group. We collected and compared demographic data, clinical features, laboratory findings, an allergy history, and disease course of both cohorts.
Among 35 patients with eosinophilic gastroenteritis, 18 patients met the criteria for severe disease and 17 patients for mild disease. Of the patients with severe eosinophilic gastroenteritis, 6 (38%) had remission without chronic symptoms, whereas 10 (63%) had chronic symptoms requiring chronic medical therapy. Of the mild group, 12 patients (80%) had disease remission without chronic medications. An allergy history was more common in the severe disease group (83%) compared with the mild disease group (45%). Prednisone and open capsule budesonide were the most commonly used treatment medications in both groups.
Patients with eosinophilic gastroenteritis may be characterized into 2 forms. Patients with weight loss at time of presentation, hypoalbuminemia at presentation, serosal disease involvement, or anemia at diagnosis were associated with a chronic disease course requiring chronic medications.
嗜酸粒细胞性胃肠炎的研究已经确定了广泛的疾病谱。我们旨在描述疾病的亚型，并确定每个组的结果。
这是一项来自大型三级医疗中心的回顾性队列研究，纳入了 2007 年至 2018 年期间诊断为嗜酸粒细胞性胃肠炎的 35 例患者。我们根据患者就诊时的临床表现和实验室检查结果将患者分为两组。严重疾病定义为就诊时体重减轻、就诊时低白蛋白血症、浆膜疾病受累或诊断时贫血。其余患者被标记为轻度疾病组。我们收集并比较了两组患者的人口统计学数据、临床特征、实验室检查结果、过敏史和疾病过程。
在 35 例嗜酸粒细胞性胃肠炎患者中，18 例符合严重疾病标准，17 例符合轻度疾病标准。在严重嗜酸粒细胞性胃肠炎患者中，6 例（38%）无慢性症状缓解，10 例（63%）有慢性症状需要慢性药物治疗。轻度组中，12 例（80%）患者无需慢性药物治疗即可缓解疾病。严重疾病组（83%）比轻度疾病组（45%）更常见过敏史。泼尼松和口服布地奈德胶囊是两组最常用的治疗药物。
嗜酸粒细胞性胃肠炎患者可分为两种类型。就诊时体重减轻、低白蛋白血症、浆膜疾病受累或诊断时贫血的患者与需要慢性药物治疗的慢性疾病过程相关。
