Centro de Investigaciones en Bioquímica Clínica E Inmunología, CIBICI-CONICET, Facultad de Ciencias Químicas. Universidad Nacional de Córdoba. Haya de La Torre Y Medina Allende, Ciudad Universitaria, X5016HUA, Córdoba, Argentina.
Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
Sci Rep. 2021 Oct 7;11(1):19924. doi: 10.1038/s41598-021-99279-9.
The prevalence of HPV infection and its relationship with other sexually transmitted infections was analyzed in a cohort of 117 male partners of infertile couples from Cordoba, Argentina. Semen samples and urethral swabs were obtained and the infection with HPV, Chlamydia trachomatis, HSV1, HSV2, Mycoplasma hominis and Ureaplasma urealyticum was analyzed. A prevalence of HPV infection of 27.4% was found. Interestingly, infections by exclusively low risk HPV genotypes or high/intermediate risk HPV genotypes were present in 64.5% and 22.6% of cases, respectively. Low risk-HPV6 was the most frequently detected genotype. Remarkably, HPV and C. trachomatis infections were significantly associated to each other (OR: 11.55, 95% CI 1.14-117.06). No significant differences in sperm quality were found between HPV-positive and HPV-negative patients indicating that HPV male urogenital infection does not impair sperm quality. Our results show a high prevalence of HPV urogenital infection among male partners of infertile couples, and that HPV and C. trachomatis infections are reciprocal risk factors of their co-infection. Moreover, our results suggest that men constitute a reservoir for continued transmission of C. trachomatis and HPV to women highlighting the need for routine screening for these two pathogens in male partners of infertile couples.
本研究分析了来自阿根廷科尔多瓦的 117 对不孕夫妇中男性伴侣的 HPV 感染及其与其他性传播感染的关系。采集精液样本和尿道拭子，并分析 HPV、沙眼衣原体、单纯疱疹病毒 1 型、单纯疱疹病毒 2 型、人型支原体和解脲支原体的感染情况。结果发现 HPV 感染的患病率为 27.4%。有趣的是，单纯低危型 HPV 基因型或高低危型 HPV 基因型感染分别占 64.5%和 22.6%。低危型 HPV6 是最常检测到的基因型。值得注意的是，HPV 和沙眼衣原体感染之间存在显著相关性（OR：11.55，95%CI 1.14-117.06）。HPV 阳性和 HPV 阴性患者的精子质量无显著差异，提示 HPV 男性泌尿生殖系感染不会损害精子质量。本研究结果表明，不孕夫妇中男性伴侣的 HPV 泌尿生殖系感染患病率较高，HPV 和沙眼衣原体感染是其共同感染的相互危险因素。此外，本研究结果表明，男性是沙眼衣原体和 HPV 向女性持续传播的储主，强调了在不孕夫妇的男性伴侣中常规筛查这两种病原体的必要性。
