Sichero Laura, Giuliano Anna R, Villa Luisa Lina
Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brazil.
Center for Immunization and Infection Research in Cancer, and the Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Acta Cytol. 2019;63(2):109-117. doi: 10.1159/000493737. Epub 2019 Feb 22.
It is currently recognized that in addition to the major impact of human papillomavirus (HPV) infection in females, HPV causes considerable disease in men at the genitals, anal canal, and oropharynx. Specifically, genital HPV infections may progress to genital warts and penile carcinoma. Although studies concerning the natural history of HPV infections and associated neoplasias have mainly focused on women, during the last 2 decades considerable attention has been given in further understanding these infections in men. The HIM (HPV infection in men) Study, the only prospective multicenter study of male HPV natural history, consisted of a large prospective international cohort study in which men from Brazil, the United States, and Mexico were enrolled. The design and protocols of this study allowed unraveling crucial information regarding the relationship between HPV infection and clinical consequences in men, and associated risk factors at each of the anatomic sites where HPV is known to cause cancer in men.
目前已认识到，除了人乳头瘤病毒（HPV）感染对女性有重大影响外，HPV还会在男性的生殖器、肛管和口咽部位引发相当多的疾病。具体而言，生殖器HPV感染可能发展为尖锐湿疣和阴茎癌。尽管关于HPV感染及相关肿瘤形成自然史的研究主要集中在女性身上，但在过去20年里，人们对进一步了解男性的这些感染给予了相当多的关注。男性HPV感染（HIM）研究是唯一一项关于男性HPV自然史的前瞻性多中心研究，它包括一项大型前瞻性国际队列研究，来自巴西、美国和墨西哥的男性参与其中。这项研究的设计和方案有助于揭示关于HPV感染与男性临床后果之间关系以及HPV已知会在男性体内引发癌症的各个解剖部位的相关风险因素的关键信息。
