异维A酸对单核细胞趋化性的体外作用。

In vitro effect of isotretinoin on monocyte chemotaxis.

作者信息

Falcon R H, Lee W L, Shalita A R, Suntharalingam K, Fikrig S M

出版信息

J Invest Dermatol. 1986 May;86(5):550-2. doi: 10.1111/1523-1747.ep12355006.

Abstract

The effect of isotretinoin on the chemotaxis of human monocytes was studied in an in vitro system using a Nucleopore chamber. The chemoattractant used was zymosan-activated serum. Inhibition of monocyte chemotaxis was achieved with isotretinoin in concentrations of 1 X 10(-3) M and 5 X 10(-4) M. It is felt that the improvement seen in patients with inflammatory skin diseases such as cystic acne and acne conglobata who are treated with isotretinoin may in part be a result of this anti-inflammatory action.

摘要

在体外系统中使用核孔小室研究了异维A酸对人单核细胞趋化性的影响。所用的趋化剂是酵母聚糖激活的血清。浓度为1×10⁻³ M和5×10⁻⁴ M的异维A酸可抑制单核细胞趋化性。人们认为，接受异维A酸治疗的炎性皮肤病患者（如囊肿性痤疮和聚合性痤疮）病情有所改善，部分原因可能是这种抗炎作用。