Skroza Nevena, Tolino Ersilia, Balduzzi Veronica, Bernardini Nicoletta, Mambrin Alessandra, Marchesiello Anna, Marraffa Federica, Rossi Giovanni, Volpe Salvatore, Proietti Ilaria, Potenza Concetta
Dermatology Unit "Daniele Innocenzi", "A. Fiorini" Hospital, Terracina, Italy.
Front Pharmacol. 2021 Nov 12;12:733526. doi: 10.3389/fphar.2021.733526. eCollection 2021.
This retrospective single-center study analyzes the efficacy and safety of isotretinoin for the treatment of moderate to severe acne in real-life clinical practice, particularly with regard to acne severity, isotretinoin cumulative dosage, and patients' gender. The results suggest the opportunity of an early isotretinoin systemic treatment in patients affected by moderate acne and emphasize the importance of an appropriate dose adjustment in order to minimize adverse events.
这项回顾性单中心研究分析了异维A酸在现实临床实践中治疗中度至重度痤疮的疗效和安全性，特别是在痤疮严重程度、异维A酸累积剂量和患者性别方面。结果表明，对于中度痤疮患者，有机会尽早进行异维A酸全身治疗，并强调了适当调整剂量以尽量减少不良事件的重要性。
