Pigatto P D, Fioroni A, Riva F, Brugo M A, Morandotti A, Altomare G F, Finzi A F
Dermatologica. 1983;167(1):16-8. doi: 10.1159/000249738.
The authors show that the use of Isotretinoin (Ro 4-3740) in cystic acne brings a reduction of chemotactic activity of the neutrophil granulocytes, like another retinoid, Etretinate, in pustular and vulgar psoriasis. This effect of retinoids, with a direct action on the polymorphonuclear leukocytes plays an important role in the recovery of the disease.
作者表明，在囊肿性痤疮中使用异维甲酸（Ro 4-3740）可使中性粒细胞的趋化活性降低，就像另一种维甲酸依曲替酯在脓疱性和寻常性银屑病中的作用一样。维甲酸对多形核白细胞的这种直接作用在疾病的恢复中起着重要作用。
