International Journal of Pharmaceutical Compounding.
Int J Pharm Compd. 2021 Sep-Oct;25(5):403-408.
Silicone oil is commonly used for vial and cartridge stopper movement and in syringes to allow for smooth movement of the syringe plunger and removal of the contents. Particulates in injectables are a concern because the silicone oil often becomes a part of the injection solution, creating a potential for patient harm. Much has been written recently concerning silicone oil in syringes used in ophthalmology and the injections into the eye. There are methods and techniques presented here that can minimize the amount of silicone oil in the final injection that is ultimately administered to the patient. New syringe products are becoming available that are silicone oil free.
硅油常用于小瓶和胶塞的移动以及注射器中，以实现注射器柱塞的平滑移动和内容物的清除。注射剂中的颗粒是一个关注点，因为硅油通常成为注射溶液的一部分，从而对患者造成潜在危害。最近有很多关于眼科中使用的注射器和眼内注射硅油的报道。这里介绍了一些方法和技术，可以最大限度地减少最终注射给患者的硅油的量。现在有越来越多的无硅油注射器产品可供使用。
