中国人群中幽门螺杆菌感染与估算肾小球滤过率的关系。

Association of Helicobacter pylori infection with estimated glomerular filtration rate in a Chinese population.

机构信息

Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin Province, China.

Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin Province, China.

出版信息

Infect Genet Evol. 2021 Dec;96:105102. doi: 10.1016/j.meegid.2021.105102. Epub 2021 Oct 5.

DOI:10.1016/j.meegid.2021.105102

PMID:34624541

Abstract

BACKGROUND

Helicobacter pylori (H. Pylori) infection is reported to be associated with extragastric disorders which include kidney diseases. But the association between H. pylori infection and estimated glomerular filtration rate (eGFR) is unclear as far. Thus, we performed the study to investigate the prevalence of H. pylori infection and its association with eGFR in a Chinese population.

MATERIALS AND METHODS

We conducted a cross-sectional study in adults who took health examination at the First Hospital of Jilin University in 2019. All the subjects received C-labled urea breath test to determine the H. pylori infection, and we analyzed the relationship between prevalence of H. pylori infection and eGFR.

RESULTS

Among 3593 participants in the health checkup, the positive rate of H. pylori infection was 37.3%. H. pylori-positive participants had a lower level of eGFR than H. pylori-negative participants. In univariate analysis, we observed that the positive rate of H. pylori infection and RR (relative risk) became larger with eGFR decreased, however, the association was not significant after adjustment for other factors. Further multivariable analysis showed age and sex were the main confounders between eGFR and H. pylori infection.

CONCLUSIONS

The correlation between eGFR and positive rate of H. pylori infection was confounded by age and sex.

摘要

背景

幽门螺杆菌（H. Pylori）感染与胃外疾病有关，包括肾脏疾病。但迄今为止，H. pylori 感染与估算肾小球滤过率（eGFR）之间的关系尚不清楚。因此，我们进行了这项研究，以调查中国人群中 H. pylori 感染的流行情况及其与 eGFR 的关系。

材料和方法

我们对 2019 年在吉林大学第一医院进行健康检查的成年人进行了横断面研究。所有受试者均接受 C-标记尿素呼气试验以确定 H. pylori 感染情况，并分析 H. pylori 感染的流行率与 eGFR 之间的关系。

结果

在 3593 名参加健康检查的参与者中，H. pylori 感染的阳性率为 37.3%。H. pylori 阳性参与者的 eGFR 水平低于 H. pylori 阴性参与者。在单因素分析中，我们观察到 H. pylori 感染的阳性率和 RR（相对风险）随着 eGFR 的降低而增加，但在调整其他因素后，这种关联并不显著。进一步的多变量分析表明，年龄和性别是 eGFR 与 H. pylori 感染之间的主要混杂因素。