中国人群中幽门螺杆菌感染的患病率及其与体重指数的关系。
Prevalence of Helicobacter pylori infection and its relation with body mass index in a Chinese population.
作者信息
Xu Chengfu, Yan Ming, Sun Yan, Joo Jungsoo, Wan Xingyong, Yu Chaohui, Wang Qunyan, Shen Chao, Chen Peng, Li Youming, Coleman William G
机构信息
Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Cancer Cluster, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA; Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
出版信息
Helicobacter. 2014 Dec;19(6):437-42. doi: 10.1111/hel.12153. Epub 2014 Sep 25.
BACKGROUND
Helicobacter pylori infection is highly prevalent worldwide. The association between obesity and H. pylori infection is controversial in the literature. This study aims to investigate the prevalence of H. pylori infection and its relation with body mass index (BMI) in a Chinese population.
MATERIALS AND METHODS
A cross-sectional study was performed among adults who underwent health checkups at the First Affiliated Hospital, College of Medicine, Zhejiang University in 2013. The prevalence of H. pylori infection was examined by (13)C urea breath tests, and the association between prevalence of H. pylori infection and BMI was analyzed.
RESULTS
Of the 8820 participants enrolled, 3859 (43.8%) were positive for H. pylori infection. H. pylori-positive participants had a more unfavorable metabolic profile than H. pylori-negative participants. Overweight/obese participants showed a higher prevalence of H. pylori infection than that of lean participants, and a positive linear correlation between BMI and prevalence of H. pylori infection was observed. Both unadjusted and adjusted analysis revealed that BMI was significantly associated with risk factors of H. pylori infection.
CONCLUSIONS
Our results showed that BMI was significantly and positively associated with H. pylori infection, and a high BMI was associated with an increased risk of the infection.
背景
幽门螺杆菌感染在全球范围内高度流行。肥胖与幽门螺杆菌感染之间的关联在文献中存在争议。本研究旨在调查中国人群中幽门螺杆菌感染的患病率及其与体重指数（BMI）的关系。
材料与方法
对2013年在浙江大学医学院附属第一医院接受健康检查的成年人进行了一项横断面研究。通过¹³C尿素呼气试验检测幽门螺杆菌感染的患病率，并分析幽门螺杆菌感染患病率与BMI之间的关联。
结果
在纳入的8820名参与者中，3859名（43.8%）幽门螺杆菌感染呈阳性。幽门螺杆菌阳性参与者的代谢状况比幽门螺杆菌阴性参与者更差。超重/肥胖参与者的幽门螺杆菌感染患病率高于瘦体重参与者，并且观察到BMI与幽门螺杆菌感染患病率之间存在正线性相关性。未经调整和调整后的分析均显示，BMI与幽门螺杆菌感染的危险因素显著相关。
结论
我们的结果表明，BMI与幽门螺杆菌感染显著正相关，高BMI与感染风险增加相关。
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