Dou J R, Zhou X, Miao R F, Yang Y, Liu X, Zhang F, Zhao Y, Zhou M L
Yangzhou Center for Disease Control and Prevention, Yangzhou 225001, China.
Affiliated Hospital of Yangzhou University, Yangzhou 225009, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2021 Sep 20;39(9):676-681. doi: 10.3760/cma.j.cn121094-20201030-00601.
To explore the clinical characteristics and prognostic factors of patients with acute glyphosate poisoning, and to provide reference for the comprehensive treatment and prognosis judgment of acute glyphosate poisoning. The complete hospitalized medical records data of 40 patients with acute glyphosate poisoning who were treated in the emergency department of Affiliated Hospital of Yangzhou University from 2014 to 2019 were collected in August 2020. According to the outcome during the follow-up period of 90 d after discharge from hospital, patients were divided into survival group (=33) and treatment failure group (=7) . The clinical characteristics of the two groups were analyzed. The influencing factors of prognosis were analyzed by binary logistic regression, and the receiver operating characteristic (ROC) curve was used to evaluate the value of white blood cell count level at admission to the prognosis of patients with acute glyphosate poisoning. The average age of the 40 glyphosate poisoning patients was (57.70±19.72) years old, the oral dose was 100 (50, 200) ml, the hospital stay was 4.0 (1.0, 5.0) d, and the fatality rate was 17.5% (7/40) . The main clinical manifestations were the symptoms of the digestive tract, respiratory tract, cardiovascular system and nervous system. Logistic regression showed that white blood cell level at admission was an influencing factor for the prognosis of patients with acute glyphosate poisoning (=1.148, 95%: 1.124-1.791, =0.003) . The ROC curve showed that the best diagnostic cut-off value of white blood cell level at admission to the prognosis of acute glyphosate poisoning was 14.65×10(9)/L, the area under the curve (AUC) was 0.9351. The sensitivity was 100.00%, and the specificity was 84.85%. High level of white blood cell at admission is a risk factor for the prognosis of acute glyphosate poisoning, and white blood cell level at admission has a certain predictive value for the prognosis of acute glyphosate poisoning.
探讨急性草甘膦中毒患者的临床特征及预后因素，为急性草甘膦中毒的综合治疗及预后判断提供参考。收集2020年8月扬州大学附属医院急诊科2014年至2019年收治的40例急性草甘膦中毒患者完整的住院病历资料。根据出院后90 d随访期间的结局，将患者分为存活组（n = 33）和治疗失败组（n = 7）。分析两组的临床特征。采用二元logistic回归分析预后的影响因素，采用受试者工作特征（ROC）曲线评估入院时白细胞计数水平对急性草甘膦中毒患者预后的价值。40例草甘膦中毒患者平均年龄（57.70±19.72）岁，口服剂量为100（50，200）ml，住院时间为4.0（1.0，5.0）d，病死率为17.5%（7/40）。主要临床表现为消化道、呼吸道、心血管系统及神经系统症状。Logistic回归分析显示，入院时白细胞水平是急性草甘膦中毒患者预后的影响因素（β = 1.148，95%CI：1.124 - 1.791，P = 0.003）。ROC曲线显示，入院时白细胞水平对急性草甘膦中毒预后的最佳诊断界值为14.65×10⁹/L，曲线下面积（AUC）为0.9351。灵敏度为100.00%，特异度为84.85%。入院时白细胞水平升高是急性草甘膦中毒预后的危险因素，入院时白细胞水平对急性草甘膦中毒预后具有一定的预测价值。
